Aging: ROS or TOR - PubMed (original) (raw)

Review

. 2008 Nov 1;7(21):3344-54.

doi: 10.4161/cc.7.21.6965. Epub 2008 Nov 11.

Affiliations

• PMID: 18971624
• DOI: 10.4161/cc.7.21.6965

Review

Aging: ROS or TOR

Mikhail V Blagosklonny. Cell Cycle. 2008.

Abstract

It is widely believed that aging is caused by the accumulation of random molecular damage due to reactive oxygen species (ROS). Here I discuss evidence for and against the ROS theory. Remarkably, even supporting evidence has an alternative explanation, consistent with the model that aging is driven by the TOR (target of rapamycin) signaling pathway.

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