Telaprevir and peginterferon with or without ribavirin for chronic HCV infection - PubMed (original) (raw)
Clinical Trial
. 2009 Apr 30;360(18):1839-50.
doi: 10.1056/NEJMoa0807650.
Nicole Forestier, Geoffrey Dusheiko, Peter Ferenci, Stanislas Pol, Tobias Goeser, Jean-Pierre Bronowicki, Marc Bourlière, Shahin Gharakhanian, Leif Bengtsson, Lindsay McNair, Shelley George, Tara Kieffer, Ann Kwong, Robert S Kauffman, John Alam, Jean-Michel Pawlotsky, Stefan Zeuzem; PROVE2 Study Team
Collaborators, Affiliations
- PMID: 19403903
- DOI: 10.1056/NEJMoa0807650
Free article
Clinical Trial
Telaprevir and peginterferon with or without ribavirin for chronic HCV infection
Christophe Hézode et al. N Engl J Med. 2009.
Free article
Abstract
Background: In patients with chronic infection with hepatitis C virus (HCV) genotype 1, treatment with peginterferon alfa and ribavirin for 48 weeks results in rates of sustained virologic response of 40 to 50%. Telaprevir is a specific inhibitor of the HCV serine protease and could be of value in HCV treatment.
Methods: A total of 334 patients who had chronic infection with HCV genotype 1 and had not been treated previously were randomly assigned to receive one of four treatments involving various combinations of telaprevir (1250 mg on day 1, then 750 mg every 8 hours), peginterferon alfa-2a (180 microg weekly), and ribavirin (dose according to body weight). The T12PR24 group (81 patients) received telaprevir, peginterferon alfa-2a, and ribavirin for 12 weeks, followed by peginterferon alfa-2a and ribavirin for 12 more weeks. The T12PR12 group (82 patients) received telaprevir, peginterferon alfa-2a, and ribavirin for 12 weeks. The T12P12 group (78 patients) received telaprevir and peginterferon alfa-2a without ribavirin for 12 weeks. The PR48 (control) group (82 patients) received peginterferon alfa-2a and ribavirin for 48 weeks. The primary end point, a sustained virologic response (an undetectable HCV RNA level 24 weeks after the end of therapy), was compared between the control group and the combined T12P12 and T12PR12 groups.
Results: The rate of sustained virologic response for the T12PR12 and T12P12 groups combined was 48% (77 of 160 patients), as compared with 46% (38 of 82) in the PR48 (control) group (P=0.89). The rate was 60% (49 of 82 patients) in the T12PR12 group (P=0.12 for the comparison with the PR48 group), as compared with 36% (28 of 78 patients) in the T12P12 group (P=0.003; P=0.20 for the comparison with the PR48 group). The rate was significantly higher in the T12PR24 group (69% [56 of 81 patients]) than in the PR48 group (P=0.004). The adverse events with increased frequency in the telaprevir-based groups were pruritus, rash, and anemia.
Conclusions: In this phase 2 study of patients infected with HCV genotype 1 who had not been treated previously, one of the three telaprevir groups had a significantly higher rate of sustained virologic response than that with standard therapy. Response rates were lowest with the regimen that did not include ribavirin. (ClinicalTrials.gov number, NCT00372385.)
2009 Massachusetts Medical Society
Comment in
- A step forward in therapy for hepatitis C.
Hoofnagle JH. Hoofnagle JH. N Engl J Med. 2009 Apr 30;360(18):1899-901. doi: 10.1056/NEJMe0901869. N Engl J Med. 2009. PMID: 19403908 No abstract available. - Telaprevir for chronic HCV infection.
van der Meer AJ, de Knegt RJ. van der Meer AJ, et al. N Engl J Med. 2009 Jul 30;361(5):533-4; author reply 534-5. doi: 10.1056/NEJMc091186. N Engl J Med. 2009. PMID: 19641215 No abstract available. - Telaprevir for chronic HCV infection.
Kao JH. Kao JH. N Engl J Med. 2009 Jul 30;361(5):534; author reply 534-5. N Engl J Med. 2009. PMID: 19645083 No abstract available. - New hope for a cure for chronic hepatitis C.
Reesink HW, Weegink CJ. Reesink HW, et al. J Hepatol. 2009 Oct;51(4):835-7. doi: 10.1016/j.jhep.2009.07.007. Epub 2009 Jul 21. J Hepatol. 2009. PMID: 19664837 No abstract available. - A glimpse of future hepatitis C virus treatment paradigms.
Terrault N, Khalili M. Terrault N, et al. Hepatology. 2010 Feb;51(2):707-10. doi: 10.1002/hep.23523. Hepatology. 2010. PMID: 20104511 No abstract available.
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