AngiomiRs--key regulators of angiogenesis - PubMed (original) (raw)
Review
AngiomiRs--key regulators of angiogenesis
Shusheng Wang et al. Curr Opin Genet Dev. 2009 Jun.
Abstract
The formation of new blood vessels through the process of angiogenesis is critical in vascular development and homeostasis. Aberrant angiogenesis leads to a variety of diseases, such as ischemia and cancer. Recent studies have revealed important roles for miRNAs in regulating endothelial cell (EC) function, especially angiogenesis. Mice with EC-specific deletion of Dicer, a key enzyme for generating miRNAs, display defective postnatal angiogenesis. Specific miRNAs (angiomiRs) have recently been shown to regulate angiogenesis in vivo. miRNA-126, an EC-restricted miRNA, regulates vascular integrity and developmental angiogenesis. miR-378, miR-296, and the miR-17-92 cluster contribute to tumor angiogenesis. Manipulating angiomiRs in the settings of pathological vascularization represents a new therapeutic approach.
Figures
Fig. 1
Cell-autonomous regulation of angiogenesis by miRNAs. Endothelial miRNAs regulate the angiogenic response to multiple growth factors by targeting angiogenic factors, receptors and signaling molecules. miR-126, miR-130a, miR-210, and miR-296 are considered as pro-angiomiRs; while miR-221/222, miR-320 are believed to be anti-angiomiRs. Regulation, targets and regulators for these miRNAs are indicated.
Fig. 2
Non-cell-autonomous regulation of angiogenesis by miRNAs. Non EC cells, such as tumor cells, express miRNAs which can regulate the expression of angiogenic factors or inhibitors, thereby modulating angiogenesis in a non-cell-autonomous manner. The targets and regulators for these miRNAs are indicated.
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