Effects of mulberry (Morus alba L.) extracts on lipid homeostasis in vitro and in vivo - PubMed (original) (raw)
. 2009 Aug 26;57(16):7605-11.
doi: 10.1021/jf9014697.
Affiliations
- PMID: 19630385
- DOI: 10.1021/jf9014697
Effects of mulberry (Morus alba L.) extracts on lipid homeostasis in vitro and in vivo
Li-Kaung Liu et al. J Agric Food Chem. 2009.
Abstract
The objective of this study was to investigate the lipid-lowering effects of mulberry water extracts (MWEs). To evaluate the hypolipidemic effect of MWEs, hamsters were fed with either high fat/cholesterol diets (HFCD) or HFCD supplemented with 1 and 2% MWEs for 12 weeks. Plasma total cholesterol (TC) and triglyceride (TG) levels of hamsters fed HFCD with MWEs were significantly reduced by about 30-37% and 16-35%, respectively, as compared to those without MWEs. Similar results were also measured in hepatic TC and TG of hamsters fed HFCD with MWEs. Low-density lipoprotein receptor (LDLR) gene expression and the uptake ability of low-density lipoprotein (LDL) in HepG2 cells were also upregulated by additions of MWEs. MWEs also decreased the gene expressions of enzymes involved in the TG and TC biosyntheses. Results suggest that hypolipidemic effects of MWEs are via an enhancement of LDLR gene expression and the clearance ability of LDL and a decrease in the lipid biosynthesis. Therefore, MWEs could be used as a natural agent against hyperlipidemia.
Similar articles
- Mulberry water extracts possess an anti-obesity effect and ability to inhibit hepatic lipogenesis and promote lipolysis.
Peng CH, Liu LK, Chuang CM, Chyau CC, Huang CN, Wang CJ. Peng CH, et al. J Agric Food Chem. 2011 Mar 23;59(6):2663-71. doi: 10.1021/jf1043508. Epub 2011 Mar 1. J Agric Food Chem. 2011. PMID: 21361295 - Mulberry extract inhibits oleic acid-induced lipid accumulation via reduction of lipogenesis and promotion of hepatic lipid clearance.
Ou TT, Hsu MJ, Chan KC, Huang CN, Ho HH, Wang CJ. Ou TT, et al. J Sci Food Agric. 2011 Dec;91(15):2740-8. doi: 10.1002/jsfa.4489. Epub 2011 Oct 17. J Sci Food Agric. 2011. PMID: 22002411 - Mulberry anthocyanins inhibit oleic acid induced lipid accumulation by reduction of lipogenesis and promotion of hepatic lipid clearance.
Chang JJ, Hsu MJ, Huang HP, Chung DJ, Chang YC, Wang CJ. Chang JJ, et al. J Agric Food Chem. 2013 Jun 26;61(25):6069-76. doi: 10.1021/jf401171k. Epub 2013 Jun 17. J Agric Food Chem. 2013. PMID: 23731091 - Hypolipidemic and antioxidant effects of Morus alba L. (Egyptian mulberry) root bark fractions supplementation in cholesterol-fed rats.
El-Beshbishy HA, Singab AN, Sinkkonen J, Pihlaja K. El-Beshbishy HA, et al. Life Sci. 2006 May 1;78(23):2724-33. doi: 10.1016/j.lfs.2005.10.010. Epub 2005 Nov 28. Life Sci. 2006. PMID: 16313926 - Morus alba (mulberry), a natural potent compound in management of obesity.
Mahboubi M. Mahboubi M. Pharmacol Res. 2019 Aug;146:104341. doi: 10.1016/j.phrs.2019.104341. Epub 2019 Jul 2. Pharmacol Res. 2019. PMID: 31276774 Review.
Cited by
- The Darker the Better: Identification of Chemotype Profile in Soroses of Local and Introduced Mulberry Varieties with Respect to the Colour Type.
Urbanek Krajnc A, Senekovič J, Cappellozza S, Mikulic-Petkovsek M. Urbanek Krajnc A, et al. Foods. 2023 Oct 31;12(21):3985. doi: 10.3390/foods12213985. Foods. 2023. PMID: 37959104 Free PMC article. - The Prebiotic Effects of an Extract with Antioxidant Properties from Morus alba L. Contribute to Ameliorate High-Fat Diet-Induced Obesity in Mice.
Rodríguez-Sojo MJ, Ruiz-Malagón AJ, Hidalgo-García L, Molina-Tijeras JA, Diez-Echave P, López-Escanez L, Rosati L, González-Lozano E, Cenis-Cifuentes L, García-García J, García F, Robles-Vera I, Romero M, Duarte J, Cenis JL, Lozano-Pérez AA, Gálvez J, Rodríguez-Cabezas ME, Rodríguez-Nogales A. Rodríguez-Sojo MJ, et al. Antioxidants (Basel). 2023 Apr 21;12(4):978. doi: 10.3390/antiox12040978. Antioxidants (Basel). 2023. PMID: 37107352 Free PMC article. - Mulberry leaves juice attenuates arsenic-induced neurobehavioral and hepatic disorders in mice.
Islam Z, Islam J, Tony SR, Anjum A, Ferdous R, Roy AK, Hossain S, Salam KA, Nikkon F, Hossain K, Saud ZA. Islam Z, et al. Food Sci Nutr. 2022 Aug 17;10(12):4360-4370. doi: 10.1002/fsn3.3028. eCollection 2022 Dec. Food Sci Nutr. 2022. PMID: 36514774 Free PMC article. - Mulberry (Morus alba L.) Fruit Extract Ameliorates Inflammation via Regulating MicroRNA-21/132/143 Expression and Increases the Skeletal Muscle Mitochondrial Content and AMPK/SIRT Activities.
Jung S, Lee MS, Chang E, Kim CT, Kim Y. Jung S, et al. Antioxidants (Basel). 2021 Sep 13;10(9):1453. doi: 10.3390/antiox10091453. Antioxidants (Basel). 2021. PMID: 34573085 Free PMC article. - The Therapeutic Effects and Mechanisms of Quercetin on Metabolic Diseases: Pharmacological Data and Clinical Evidence.
Yi H, Peng H, Wu X, Xu X, Kuang T, Zhang J, Du L, Fan G. Yi H, et al. Oxid Med Cell Longev. 2021 Jun 23;2021:6678662. doi: 10.1155/2021/6678662. eCollection 2021. Oxid Med Cell Longev. 2021. PMID: 34257817 Free PMC article. Review.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Miscellaneous