From IL-10 to IL-12: how pathogens and their products stimulate APCs to induce T(H)1 development - PubMed (original) (raw)
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From IL-10 to IL-12: how pathogens and their products stimulate APCs to induce T(H)1 development
Anne O'Garra et al. Nat Immunol. 2009 Sep.
Abstract
The authors recount their discovery of how pathogen-induced interleukin 12 production leads to T(H)1 T cell polarization. Simultaneously they discovered the suppressive cytokine interleukin 10 inhibits antigen-presenting cells, thus regulating development of T(H)1 cells.
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References
- Int Immunol. 1990;2(9):821-32 - PubMed
- J Exp Med. 1989 Dec 1;170(6):2081-95 - PubMed
- J Exp Med. 1994 Jul 1;180(1):223-31 - PubMed
- Proc Natl Acad Sci U S A. 1992 Jul 1;89(13):6065-9 - PubMed
- J Exp Med. 1995 May 1;181(5):1755-62 - PubMed
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