Tetraspanin-enriched microdomains: a functional unit in cell plasma membranes - PubMed (original) (raw)

Review

Tetraspanin-enriched microdomains: a functional unit in cell plasma membranes

María Yáñez-Mó et al. Trends Cell Biol. 2009 Sep.

Abstract

Membrane lipids and proteins are non-randomly distributed and are unable to diffuse freely in the plane of the membrane. This is because of multiple constraints imposed both by the cortical cytoskeleton and by the preference of lipids and proteins to cluster into diverse and specialized membrane domains, including tetraspanin-enriched microdomains, glycosylphosphatidyl inositol-linked proteins nanodomains and caveolae, among others. Recent biophysical characterization of tetraspanin-enriched microdomains suggests that they might be specially suited for the regulation of avidity of adhesion receptors and the compartmentalization of enzymatic activities. Moreover, modulation by tetraspanins of the function of adhesion receptors involved in inflammation, lymphocyte activation, cancer and pathogen infection suggests potential as therapeutic targets. This review explores this emerging picture of tetraspanin microdomains and discusses the implications for cell adhesion, proteolysis and pathogenesis.

PubMed Disclaimer

Similar articles

• Tetraspanin microdomains in immune cell signalling and malignant disease.
  Wright MD, Moseley GW, van Spriel AB. Wright MD, et al. Tissue Antigens. 2004 Nov;64(5):533-42. doi: 10.1111/j.1399-0039.2004.00321.x. Tissue Antigens. 2004. PMID: 15496196 Review.
• Membrane microdomains and proteomics: lessons from tetraspanin microdomains and comparison with lipid rafts.
  Le Naour F, André M, Boucheix C, Rubinstein E. Le Naour F, et al. Proteomics. 2006 Dec;6(24):6447-54. doi: 10.1002/pmic.200600282. Proteomics. 2006. PMID: 17109380 Review.
• Lateral organization of membrane proteins: tetraspanins spin their web.
  Charrin S, le Naour F, Silvie O, Milhiet PE, Boucheix C, Rubinstein E. Charrin S, et al. Biochem J. 2009 May 13;420(2):133-54. doi: 10.1042/BJ20082422. Biochem J. 2009. PMID: 19426143 Review.
• Protein-protein interactions in the tetraspanin web.
  Levy S, Shoham T. Levy S, et al. Physiology (Bethesda). 2005 Aug;20:218-24. doi: 10.1152/physiol.00015.2005. Physiology (Bethesda). 2005. PMID: 16024509 Review.
• The tetraspanin web modulates immune-signalling complexes.
  Levy S, Shoham T. Levy S, et al. Nat Rev Immunol. 2005 Feb;5(2):136-48. doi: 10.1038/nri1548. Nat Rev Immunol. 2005. PMID: 15688041 Review.

Cited by

• Migrasomes: Biogenesis, physiological roles, and therapeutic potentials.
  Jiao H, Yu L. Jiao H, et al. J Cell Biol. 2024 Nov 4;223(11):e202403051. doi: 10.1083/jcb.202403051. Epub 2024 Oct 14. J Cell Biol. 2024. PMID: 39400310 Free PMC article. Review.
• Tetraspanin-enriched microdomains play an important role in pathogenesis in the protozoan parasite Entamoeba histolytica.
  Jiang H, Santos HJ, Nozaki T. Jiang H, et al. PLoS Pathog. 2024 Oct 3;20(10):e1012151. doi: 10.1371/journal.ppat.1012151. eCollection 2024 Oct. PLoS Pathog. 2024. PMID: 39361713 Free PMC article.
• Proteomic landscape of tunneling nanotubes reveals CD9 and CD81 tetraspanins as key regulators.
  Notario Manzano R, Chaze T, Rubinstein E, Penard E, Matondo M, Zurzolo C, Brou C. Notario Manzano R, et al. Elife. 2024 Sep 9;13:RP99172. doi: 10.7554/eLife.99172. Elife. 2024. PMID: 39250349 Free PMC article.
• Human tetraspanin CD81 facilitates invasion of Salmonella enterica into human epithelial cells.
  Alvarez KG, Goral L, Suwandi A, Lasswitz L, Zapatero-Belinchón FJ, Ehrhardt K, Nagarathinam K, Künnemann K, Krey T, Wiedemann A, Gerold G, Grassl GA. Alvarez KG, et al. Virulence. 2024 Dec;15(1):2399792. doi: 10.1080/21505594.2024.2399792. Epub 2024 Sep 24. Virulence. 2024. PMID: 39239914 Free PMC article.
• Extracellular vesicles (EVs)' journey in recipient cells: from recognition to cargo release.
  Xiang H, Bao C, Chen Q, Gao Q, Wang N, Gao Q, Mao L. Xiang H, et al. J Zhejiang Univ Sci B. 2024 Aug 15;25(8):633-655. doi: 10.1631/jzus.B2300566. J Zhejiang Univ Sci B. 2024. PMID: 39155778 Free PMC article. Review.

Publication types

MeSH terms

Substances

LinkOut - more resources

• Full Text Sources

  • ClinicalKey
  • Elsevier Science

• Other Literature Sources

  • The Lens - Patent Citations