Control of lung epithelial growth by a nicotinic acetylcholine receptor: the other side of the coin - PubMed (original) (raw)

Comment

Control of lung epithelial growth by a nicotinic acetylcholine receptor: the other side of the coin

Jesse Roman et al. Am J Pathol. 2009 Nov.

Abstract

This Commentary provides a perspective on an article in the current issue of the American Journal of Pathology by Maouche et al, which demonstrates that alpha7 nicotinic acetylcholine receptors play a key role in regulating airway regeneration by limiting basal epithelial cell proliferation.

PubMed Disclaimer

Comment on

• {alpha}7 nicotinic acetylcholine receptor regulates airway epithelium differentiation by controlling basal cell proliferation.
  Maouche K, Polette M, Jolly T, Medjber K, Cloëz-Tayarani I, Changeux JP, Burlet H, Terryn C, Coraux C, Zahm JM, Birembaut P, Tournier JM. Maouche K, et al. Am J Pathol. 2009 Nov;175(5):1868-82. doi: 10.2353/ajpath.2009.090212. Epub 2009 Oct 1. Am J Pathol. 2009. PMID: 19808646 Free PMC article.

Similar articles

• {alpha}7 nicotinic acetylcholine receptor regulates airway epithelium differentiation by controlling basal cell proliferation.
  Maouche K, Polette M, Jolly T, Medjber K, Cloëz-Tayarani I, Changeux JP, Burlet H, Terryn C, Coraux C, Zahm JM, Birembaut P, Tournier JM. Maouche K, et al. Am J Pathol. 2009 Nov;175(5):1868-82. doi: 10.2353/ajpath.2009.090212. Epub 2009 Oct 1. Am J Pathol. 2009. PMID: 19808646 Free PMC article.
• α7 nAChR in airway respiratory epithelial cells.
  Nastrucci C, Russo P. Nastrucci C, et al. Curr Drug Targets. 2012 May;13(5):666-70. doi: 10.2174/138945012800398865. Curr Drug Targets. 2012. PMID: 22300033 Review.
• Nicotine reduces TNF-α expression through a α7 nAChR/MyD88/NF-ĸB pathway in HBE16 airway epithelial cells.
  Li Q, Zhou XD, Kolosov VP, Perelman JM. Li Q, et al. Cell Physiol Biochem. 2011;27(5):605-12. doi: 10.1159/000329982. Epub 2011 Jun 15. Cell Physiol Biochem. 2011. PMID: 21691078
• Nicotine signals through muscle-type and neuronal nicotinic acetylcholine receptors in both human bronchial epithelial cells and airway fibroblasts.
  Carlisle DL, Hopkins TM, Gaither-Davis A, Silhanek MJ, Luketich JD, Christie NA, Siegfried JM. Carlisle DL, et al. Respir Res. 2004 Dec 10;5(1):27. doi: 10.1186/1465-9921-5-27. Respir Res. 2004. PMID: 15588326 Free PMC article.
• Alpha-bungarotoxin binding and central nervous system nicotinic acetylcholine receptors.
  Oswald RE, Freeman JA. Oswald RE, et al. Neuroscience. 1981;6(1):1-14. doi: 10.1016/0306-4522(81)90239-6. Neuroscience. 1981. PMID: 7012663 Review. No abstract available.

Cited by

• WNT signaling - lung cancer is no exception.
  Rapp J, Jaromi L, Kvell K, Miskei G, Pongracz JE. Rapp J, et al. Respir Res. 2017 Sep 5;18(1):167. doi: 10.1186/s12931-017-0650-6. Respir Res. 2017. PMID: 28870231 Free PMC article. Review.
• The Protective Effect of Alpha 7 Nicotinic Acetylcholine Receptor Activation on Critical Illness and Its Mechanism.
  Ren C, Tong YL, Li JC, Lu ZQ, Yao YM. Ren C, et al. Int J Biol Sci. 2017 Jan 1;13(1):46-56. doi: 10.7150/ijbs.16404. eCollection 2017. Int J Biol Sci. 2017. PMID: 28123345 Free PMC article. Review.
• Vagus nerve through α7 nAChR modulates lung infection and inflammation: models, cells, and signals.
  Wu H, Li L, Su X. Wu H, et al. Biomed Res Int. 2014;2014:283525. doi: 10.1155/2014/283525. Epub 2014 Jul 20. Biomed Res Int. 2014. PMID: 25136575 Free PMC article.
• The ly-6 protein, lynx1, is an endogenous inhibitor of nicotinic signaling in airway epithelium.
  Fu XW, Rekow SS, Spindel ER. Fu XW, et al. Am J Physiol Lung Cell Mol Physiol. 2012 Oct 15;303(8):L661-8. doi: 10.1152/ajplung.00075.2012. Epub 2012 Aug 24. Am J Physiol Lung Cell Mol Physiol. 2012. PMID: 22923641 Free PMC article.

References

1. 1. Egleton RD, Brown KC, Dasgupta P. Nicotinic acetylcholine receptors in cancer: multiple roles in proliferation and inhibition of apoptosis. Trends Pharmacol Sci. 2008;29:151–158. - PubMed
2. 1. Zheng Y, Ritzenthaler JD, Roman J, Han S. Nicotine stimulates human lung cancer cell growth by inducing fibronectin expression. Am J Respir Cell Mol Biol. 2007;37:681–690. - PubMed
3. 1. Kummer W, Lips KS, Pfeil U. The epithelial cholinergic system of the airways. Histochem Cell Biol. 2008;130:219–234. - PMC - PubMed
4. 1. Maouche K, Polette M, Jolly T, Cloez-Tayarani I, Changeux J-P, Burlet H, Terryn C, Coraux C, Zahm J-M, Birembaut P, Tournier J-M. α7 nicotinic acetylcholine receptor regulates airway epithelium differentiation by controlling basal cell proliferation, Am J Pathol. 2009;175:1862–1876. - PMC - PubMed
5. 1. Arredondo J, Nguyen VT, Chernyavsky AI, Bercovich D, Orr-Urtreger A, Kummer W, Lips K, Vetter DE, Grando SA. Central role of α7 nicotinic receptor in differentiation of the stratified squamous epithelium. J Cell Biol. 2002;159:325–336. - PMC - PubMed

Publication types

MeSH terms

Substances

LinkOut - more resources

• Full Text Sources

  • ClinicalKey
  • Elsevier Science
  • Europe PubMed Central
  • PubMed Central