The Runx3 transcription factor augments Th1 and down-modulates Th2 phenotypes by interacting with and attenuating GATA3 - PubMed (original) (raw)
Comparative Study
. 2009 Dec 15;183(12):7817-24.
doi: 10.4049/jimmunol.0802527.
Affiliations
- PMID: 19933870
- DOI: 10.4049/jimmunol.0802527
Comparative Study
The Runx3 transcription factor augments Th1 and down-modulates Th2 phenotypes by interacting with and attenuating GATA3
Kazuyoshi Kohu et al. J Immunol. 2009.
Abstract
Recently, it was reported that the expression of Runt-related transcription factor 3 (Runx3) is up-regulated in CD4(+) helper T cells during Th1 cell differentiation, and that Runx3 functions in a positive feed-forward manner with the T-box family transcription factor, T-bet, which is a master regulator of Th1 cell differentiation. The relative expression levels of IFN-gamma and IL-4 are also regulated by the Th2-associated transcription factor, GATA3. Here, we demonstrate that Runx3 was induced in Th2 as well as Th1 cells and that Runx3 interacted with GATA3 and attenuated GATA3 transcriptional activity. Ectopic expression of Runx3 in vitro in cultured cells or transgenic expression of Runx3 in mice accelerated CD4(+) cells to a Th1-biased population or down-modulated Th2 responses, in part by neutralizing GATA3. Our results suggest that the balance of Runx3 and GATA3 is one factor that influences the manifestation of CD4(+) cells as the Th1 or Th2 phenotypes.
Similar articles
- The transcription factor GATA3 actively represses RUNX3 protein-regulated production of interferon-gamma.
Yagi R, Junttila IS, Wei G, Urban JF Jr, Zhao K, Paul WE, Zhu J. Yagi R, et al. Immunity. 2010 Apr 23;32(4):507-17. doi: 10.1016/j.immuni.2010.04.004. Epub 2010 Apr 15. Immunity. 2010. PMID: 20399120 Free PMC article. - Enforced expression of GATA-3 in transgenic mice inhibits Th1 differentiation and induces the formation of a T1/ST2-expressing Th2-committed T cell compartment in vivo.
Nawijn MC, Dingjan GM, Ferreira R, Lambrecht BN, Karis A, Grosveld F, Savelkoul H, Hendriks RW. Nawijn MC, et al. J Immunol. 2001 Jul 15;167(2):724-32. doi: 10.4049/jimmunol.167.2.724. J Immunol. 2001. PMID: 11441076 - Direct regulation of Gata3 expression determines the T helper differentiation potential of Notch.
Amsen D, Antov A, Jankovic D, Sher A, Radtke F, Souabni A, Busslinger M, McCright B, Gridley T, Flavell RA. Amsen D, et al. Immunity. 2007 Jul;27(1):89-99. doi: 10.1016/j.immuni.2007.05.021. Epub 2007 Jul 19. Immunity. 2007. PMID: 17658279 Free PMC article. - An updated view on transcription factor GATA3-mediated regulation of Th1 and Th2 cell differentiation.
Yagi R, Zhu J, Paul WE. Yagi R, et al. Int Immunol. 2011 Jul;23(7):415-20. doi: 10.1093/intimm/dxr029. Epub 2011 Jun 1. Int Immunol. 2011. PMID: 21632975 Free PMC article. Review. - The function role of GATA-3 in Th1 and Th2 differentiation.
Zhou M, Ouyang W. Zhou M, et al. Immunol Res. 2003;28(1):25-37. doi: 10.1385/IR:28:1:25. Immunol Res. 2003. PMID: 12947222 Review.
Cited by
- Differentiation and regulation of CD4+ T cell subsets in Parkinson's disease.
Sun X, Gu R, Bai J. Sun X, et al. Cell Mol Life Sci. 2024 Aug 17;81(1):352. doi: 10.1007/s00018-024-05402-0. Cell Mol Life Sci. 2024. PMID: 39153043 Free PMC article. Review. - The role of miRNAs in T helper cell development, activation, fate decisions and tumor immunity.
Xu SJ, Chen JH, Chang S, Li HL. Xu SJ, et al. Front Immunol. 2024 Jan 9;14:1320305. doi: 10.3389/fimmu.2023.1320305. eCollection 2023. Front Immunol. 2024. PMID: 38264670 Free PMC article. Review. - Counteracting Immunosenescence-Which Therapeutic Strategies Are Promising?
Hieber C, Grabbe S, Bros M. Hieber C, et al. Biomolecules. 2023 Jul 6;13(7):1085. doi: 10.3390/biom13071085. Biomolecules. 2023. PMID: 37509121 Free PMC article. Review. - Transcriptional programming of CD4+ TRM differentiation in viral infection balances effector- and memory-associated gene expression.
Nguyen QP, Takehara KK, Deng TZ, O'Shea S, Heeg M, Omilusik KD, Milner JJ, Quon S, Pipkin ME, Choi J, Crotty S, Goldrath AW. Nguyen QP, et al. Sci Immunol. 2023 May 12;8(83):eabq7486. doi: 10.1126/sciimmunol.abq7486. Epub 2023 May 12. Sci Immunol. 2023. PMID: 37172104 Free PMC article. - [Changes in percentage of GATA3+ regulatory T cells and their pathogenic roles in allergic rhinitis].
Sun L, Jiao W, Kong Y, Yang C, Xu S, Qiao Y, Chen S. Sun L, et al. Nan Fang Yi Ke Da Xue Xue Bao. 2023 Feb 20;43(2):280-286. doi: 10.12122/j.issn.1673-4254.2023.02.17. Nan Fang Yi Ke Da Xue Xue Bao. 2023. PMID: 36946049 Free PMC article. Chinese.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Molecular Biology Databases
Research Materials
Miscellaneous