Antigen presentation in the thymus for positive selection and central tolerance induction - PubMed (original) (raw)
Review
doi: 10.1038/nri2669.
Affiliations
- PMID: 19935803
- DOI: 10.1038/nri2669
Review
Antigen presentation in the thymus for positive selection and central tolerance induction
Ludger Klein et al. Nat Rev Immunol. 2009 Dec.
Abstract
Understanding how thymic selection imparts self-peptide-MHC complex restriction and a high degree of self tolerance on the T cell repertoire requires a detailed description of the parameters that shape the MHC ligand repertoire of distinct thymic antigen-presenting cells and of how these cells communicate with T cells. Several recent discoveries pertaining to cortex-specific pathways of antigen processing, the heterogeneity of thymic dendritic cells and the intercellular transfer of self antigens have uncovered surprising and unique aspects of antigen presentation in the thymic microenvironment. Here, we discuss these new findings in the context of how individual thymic stromal cell types support T cell selection in a cooperative rather than a redundant manner.
Similar articles
- Thymic T-cell tolerance of neuroendocrine functions: physiology and pathophysiology.
Geenen V, Kecha O, Brilot F, Hansenne I, Renard C, Martens H. Geenen V, et al. Cell Mol Biol (Noisy-le-grand). 2001 Feb;47(1):179-88. Cell Mol Biol (Noisy-le-grand). 2001. PMID: 11292253 Review. - How thymic antigen presenting cells sample the body's self-antigens.
Derbinski J, Kyewski B. Derbinski J, et al. Curr Opin Immunol. 2010 Oct;22(5):592-600. doi: 10.1016/j.coi.2010.08.003. Epub 2010 Sep 9. Curr Opin Immunol. 2010. PMID: 20832274 Review. - Antigen processing and presentation in the thymus: implications for T cell repertoire selection.
Kondo K, Takada K, Takahama Y. Kondo K, et al. Curr Opin Immunol. 2017 Jun;46:53-57. doi: 10.1016/j.coi.2017.03.014. Epub 2017 May 3. Curr Opin Immunol. 2017. PMID: 28477557 Review. - In vivo maintenance of T-lymphocyte unresponsiveness induced by thymic medullary epithelium requires antigen presentation by radioresistant cells.
Hudrisier D, Feau S, Bonnet V, Romagnoli P, Van Meerwijk JP. Hudrisier D, et al. Immunology. 2003 Jan;108(1):24-31. doi: 10.1046/j.1365-2567.2003.01546.x. Immunology. 2003. PMID: 12519299 Free PMC article.
Cited by
- Superior antitumor immune response achieved with proton over photon immunoradiotherapy is amplified by the nanoradioenhancer NBTXR3.
Hu Y, Paris S, Sahoo N, Wang Q, Wang Q, Barsoumian HB, Huang A, Da Silva J, Bienassis C, Leyton CSK, Voss TA, Masrorpour F, Riad T, Leuschner C, Puebla-Osorio N, Gandhi S, Nguyen QN, Wang J, Cortez MA, Welsh JW. Hu Y, et al. J Nanobiotechnology. 2024 Oct 1;22(1):597. doi: 10.1186/s12951-024-02855-0. J Nanobiotechnology. 2024. PMID: 39354474 Free PMC article. - Development of the PD9-9 Monoclonal Antibody for Identifying Porcine Bone Marrow-Derived Dendritic Cells.
Kim SE, Kim YK, Oh KB, Hwang JH. Kim SE, et al. Life (Basel). 2024 Aug 23;14(9):1054. doi: 10.3390/life14091054. Life (Basel). 2024. PMID: 39337839 Free PMC article. - Deciphering the Role of Maternal Microchimerism in Offspring Autoimmunity: A Narrative Review.
Mpakosi A, Sokou R, Theodoraki M, Iacovidou N, Cholevas V, Kaliouli-Antonopoulou C. Mpakosi A, et al. Medicina (Kaunas). 2024 Sep 5;60(9):1457. doi: 10.3390/medicina60091457. Medicina (Kaunas). 2024. PMID: 39336498 Free PMC article. Review. - An in-depth understanding of the role and mechanisms of T cells in immune organ aging and age-related diseases.
Xu Y, Wang Z, Li S, Su J, Gao L, Ou J, Lin Z, Luo OJ, Xiao C, Chen G. Xu Y, et al. Sci China Life Sci. 2024 Sep 2. doi: 10.1007/s11427-024-2695-x. Online ahead of print. Sci China Life Sci. 2024. PMID: 39231902 Review. - Immune-checkpoint inhibitor-mediated myocarditis: CTLA4, PD1 and LAG3 in the heart.
Munir AZ, Gutierrez A, Qin J, Lichtman AH, Moslehi JJ. Munir AZ, et al. Nat Rev Cancer. 2024 Aug;24(8):540-553. doi: 10.1038/s41568-024-00715-5. Epub 2024 Jul 9. Nat Rev Cancer. 2024. PMID: 38982146 Review.
References
- Immunity. 1999 Aug;11(2):173-81 - PubMed
- Nat Rev Immunol. 2003 Jun;3(6):472-82 - PubMed
- Dev Cell. 2008 Sep;15(3):344-357 - PubMed
- Nat Rev Immunol. 2009 Mar;9(3):207-13 - PubMed
- Nat Genet. 1997 Dec;17(4):393-8 - PubMed
Publication types
MeSH terms
LinkOut - more resources
Full Text Sources
Research Materials