A clinical pilot study of lignin--ascorbic acid combination treatment of herpes simplex virus - PubMed (original) (raw)
Clinical Trial
. 2009 Nov-Dec;23(6):1011-6.
Affiliations
- PMID: 20023248
Free article
Clinical Trial
A clinical pilot study of lignin--ascorbic acid combination treatment of herpes simplex virus
Blanca Silvia Gonzalez Lopez et al. In Vivo. 2009 Nov-Dec.
Free article
Abstract
Antiviral drugs as well as natural remedies have been used to reduce symptoms and the rate of recurrences of herpes simplex virus type 1 (HSV-1) infection, a common disease. To evaluate anti-HSV-1 activity of a pine cone lignin and ascorbic acid treatment, a clinical pilot study was carried out. Forty-eight healthy patients of both genders between 4 and 61 years old (mean: 31+/-16 years), with active lesions of HSV-1, took part in the study. According to the HSV-1 stage at the presentation, the patients were classified into the prodromic (16 patients), erythema (11 patients), papule edema (1 patient), vesicle/pustule (13 patients) and ulcer stages (7 patients). One mg of lignin-ascorbic acid tablet or solution was orally administered three times daily for a month. Clinical evaluations were made daily the first week and at least three times a week during the second week after the onset and every six months during the subsequent year to identify recurrence episodes. The patients who began the lignin-ascorbic acid treatment within the first 48 hours of symptom onset did not develop HSV-1 characteristic lesions, whereas those patients who began the treatment later experienced a shorter duration of cold sore lesions and a decrease in the symptoms compared with previous episodes. The majority of the patients reported the reduction in the severity of symptoms and the reduction in the recurrence episodes after the lignin-ascorbic acid treatment compared with previous episodes, suggesting its possible applicability for the prevention and treatment of HSV-1 infection.
Similar articles
- An update on short-course intermittent and prevention therapies for herpes labialis.
Gilbert S, Corey L, Cunningham A, Malkin JE, Stanberry L, Whitley R, Spruance S. Gilbert S, et al. Herpes. 2007 Jun;14 Suppl 1:13A-18A. Herpes. 2007. PMID: 17877887 Review. - Efficacy of valacyclovir vs acyclovir for the prevention of recurrent herpes simplex virus eye disease: a pilot study.
Miserocchi E, Modorati G, Galli L, Rama P. Miserocchi E, et al. Am J Ophthalmol. 2007 Oct;144(4):547-51. doi: 10.1016/j.ajo.2007.06.001. Epub 2007 Aug 9. Am J Ophthalmol. 2007. PMID: 17692271 Clinical Trial. - Oral and perioral herpes simplex virus type 1 (HSV-1) infection: review of its management.
Arduino PG, Porter SR. Arduino PG, et al. Oral Dis. 2006 May;12(3):254-70. doi: 10.1111/j.1601-0825.2006.01202.x. Oral Dis. 2006. PMID: 16700734 Review. - Valacyclovir and topical clobetasol gel for the episodic treatment of herpes labialis: a patient-initiated, double-blind, placebo-controlled pilot trial.
Hull C, McKeough M, Sebastian K, Kriesel J, Spruance S. Hull C, et al. J Eur Acad Dermatol Venereol. 2009 Mar;23(3):263-7. doi: 10.1111/j.1468-3083.2008.03047.x. Epub 2009 Jan 8. J Eur Acad Dermatol Venereol. 2009. PMID: 19143902 Clinical Trial. - Clinical efficacy of topical docosanol 10% cream for herpes simplex labialis: A multicenter, randomized, placebo-controlled trial.
Sacks SL, Thisted RA, Jones TM, Barbarash RA, Mikolich DJ, Ruoff GE, Jorizzo JL, Gunnill LB, Katz DH, Khalil MH, Morrow PR, Yakatan GJ, Pope LE, Berg JE; Docosanol 10% Cream Study Group. Sacks SL, et al. J Am Acad Dermatol. 2001 Aug;45(2):222-30. doi: 10.1067/mjd.2001.116215. J Am Acad Dermatol. 2001. PMID: 11464183 Clinical Trial.
Cited by
- Review of Whole Plant Extracts With Activity Against Herpes Simplex Viruses In Vitro and In Vivo.
Garber A, Barnard L, Pickrell C. Garber A, et al. J Evid Based Integr Med. 2021 Jan-Dec;26:2515690X20978394. doi: 10.1177/2515690X20978394. J Evid Based Integr Med. 2021. PMID: 33593082 Free PMC article. Review. - High value valorization of lignin as environmental benign antimicrobial.
Chen M, Li Y, Liu H, Zhang D, Shi QS, Zhong XQ, Guo Y, Xie XB. Chen M, et al. Mater Today Bio. 2022 Dec 15;18:100520. doi: 10.1016/j.mtbio.2022.100520. eCollection 2023 Feb. Mater Today Bio. 2022. PMID: 36590981 Free PMC article. Review. - Pharmaceutical applications of lignin-derived chemicals and lignin-based materials: linking lignin source and processing with clinical indication.
Karagoz P, Khiawjan S, Marques MPC, Santzouk S, Bugg TDH, Lye GJ. Karagoz P, et al. Biomass Convers Biorefin. 2024;14(21):26553-26574. doi: 10.1007/s13399-023-03745-5. Epub 2023 Jan 21. Biomass Convers Biorefin. 2024. PMID: 39493283 Free PMC article. Review. - Novel antiviral activity of mung bean sprouts against respiratory syncytial virus and herpes simplex virus -1: an in vitro study on virally infected Vero and MRC-5 cell lines.
Hafidh RR, Abdulamir AS, Abu Bakar F, Sekawi Z, Jahansheri F, Jalilian FA. Hafidh RR, et al. BMC Complement Altern Med. 2015 Jun 11;15:179. doi: 10.1186/s12906-015-0688-2. BMC Complement Altern Med. 2015. PMID: 26062546 Free PMC article. - Quantification of the Ability of Natural Products to Prevent Herpes Virus Infection.
Fukuchi K, Sakagami H, Sugita Y, Takao K, Asai D, Terakubo S, Takemura H, Ohno H, Horiuchi M, Suguro M, Fujisawa T, Toeda K, Oizumi H, Yasui T, Oizumi T. Fukuchi K, et al. Medicines (Basel). 2020 Oct 6;7(10):64. doi: 10.3390/medicines7100064. Medicines (Basel). 2020. PMID: 33036124 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Medical