Studies on effect of piperine on oral bioavailability of ampicillin and norfloxacin - PubMed (original) (raw)

Studies on effect of piperine on oral bioavailability of ampicillin and norfloxacin

Kunchithapatham Janakiraman et al. Afr J Tradit Complement Altern Med. 2008.

Abstract

Ampicillin and Norfloxacin are used to treat variety of bacterial infections. These two drugs have low oral bioavailability. Co-administration of Piperine (20 mg/kg), an alkaloid from Piper nigrum L. enhanced oral bioavailability of Ampicillin and Norfloxacin in animal model. This is reflected in various pharmacokinetic measurements like Cmax, Tmax, AUC and t(1/2) of the above antibiotics in animal model.

Keywords: Ampicillin; Bioavailability; Norfloxacin; Phamacokinetics; Piper nigrum; Piperine.

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Figures

Figure 1

Figure 1

Effect of Piperine on bioavaialbility of Ampicillin

Figure 2

Figure 2

Effect of Piperine on bioavailability of Norfloxacin

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References

    1. Atal C K, Dubey R K, Singh J. Biochemical basis of enhanced drug bioavailability by piperine-evidence is apotent inhibitor of drug metabolism. Pharmacol Exp Ther. 1985;232:258. - PubMed
    1. Atal C K, Zutshi U, Rao P G. Scientific evidence on the role of Ayurvedic herbals on Bioavailability of drug. J Ethanopharmacol. 1981;4:117. - PubMed
    1. Bano G, Raina R K, Zutshi U. Effect of piperine on bioavailability and pharmacokinetics of propanolol and theophylline in healthy volunteers. Eur J Clin Pharmacol. 1991;41:615–617. - PubMed
    1. Bhardwaj R K, Glaeser H, Becquemont L, Klotz U, Gupta S K, Fromm M F. Piperine, a major constituent of black pepper inhibits human p-glycoprotein and CYP3A4. J Pharmacol Exp Ther. 2002;302:645–650. - PubMed
    1. Dhuley J N, Raman P H, Mujumdar A M, Naik S R. Inhibition of lipid peroxidation by piperine during experimental inflammation in rats. Indian J Exp Biol. 1993;31:443. - PubMed

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