Imaging atherosclerotic plaque inflammation by fluorodeoxyglucose with positron emission tomography: ready for prime time? - PubMed (original) (raw)
Review
. 2010 Jun 8;55(23):2527-35.
doi: 10.1016/j.jacc.2009.12.061.
Affiliations
- PMID: 20513592
- DOI: 10.1016/j.jacc.2009.12.061
Free article
Review
Imaging atherosclerotic plaque inflammation by fluorodeoxyglucose with positron emission tomography: ready for prime time?
James H F Rudd et al. J Am Coll Cardiol. 2010.
Free article
Abstract
Inflammation is a determinant of atherosclerotic plaque rupture, the event leading to most myocardial infarctions and strokes. Although conventional imaging techniques identify the site and severity of luminal stenosis, the inflammatory status of the plaque is not addressed. Positron emission tomography imaging of atherosclerosis using the metabolic marker fluorodeoxyglucose allows quantification of arterial inflammation across multiple vessels. This review sets out the background and current and potential future applications of this emerging biomarker of cardiovascular risk, along with its limitations.
Copyright 2010 American College of Cardiology Foundation. Published by Elsevier Inc. All rights reserved.
Similar articles
- FDG PET imaging and cardiovascular inflammation.
Hiari N, Rudd JH. Hiari N, et al. Curr Cardiol Rep. 2011 Feb;13(1):43-8. doi: 10.1007/s11886-010-0150-5. Curr Cardiol Rep. 2011. PMID: 20949379 Review. - Should vascular wall 18F-FDG uptake be adjusted for the extent of atherosclerotic burden?
Lensen KDF, Voskuyl AE, Comans EFI, van der Laken CJ, Boellaard R, Smulders YM. Lensen KDF, et al. Int J Cardiovasc Imaging. 2020 Mar;36(3):545-551. doi: 10.1007/s10554-019-01744-0. Epub 2020 Jan 2. Int J Cardiovasc Imaging. 2020. PMID: 31898005 - Positron emission tomography-computed tomography for imaging of inflammatory cardiovascular diseases.
Miyagawa M, Yokoyama R, Nishiyama Y, Ogimoto A, Higaki J, Mochizuki T. Miyagawa M, et al. Circ J. 2014;78(6):1302-10. doi: 10.1253/circj.cj-14-0250. Epub 2014 May 9. Circ J. 2014. PMID: 24817762 Review. - Vascular imaging with positron emission tomography.
Joshi F, Rosenbaum D, Bordes S, Rudd JH. Joshi F, et al. J Intern Med. 2011 Aug;270(2):99-109. doi: 10.1111/j.1365-2796.2011.02392.x. Epub 2011 May 18. J Intern Med. 2011. PMID: 21518037 Review. - Quantification of atherosclerotic plaque activity and vascular inflammation using [18-F] fluorodeoxyglucose positron emission tomography/computed tomography (FDG-PET/CT).
Mehta NN, Torigian DA, Gelfand JM, Saboury B, Alavi A. Mehta NN, et al. J Vis Exp. 2012 May 2;(63):e3777. doi: 10.3791/3777. J Vis Exp. 2012. PMID: 22588186 Free PMC article.
Cited by
- Inflammatory involvement in a patient with Leriche syndrome evaluated by 18F-fluorodeoxyglucose PET/MRI.
Masuda A, Yamaki T, Kunii H, Nemoto A, Kubo H, Tominaga H, Oriuchi N, Takenoshita S, Takeishi Y. Masuda A, et al. J Nucl Cardiol. 2017 Oct;24(5):1819-1821. doi: 10.1007/s12350-016-0680-3. Epub 2016 Sep 20. J Nucl Cardiol. 2017. PMID: 27650445 No abstract available. - Splenic metabolic activity predicts risk of future cardiovascular events: demonstration of a cardiosplenic axis in humans.
Emami H, Singh P, MacNabb M, Vucic E, Lavender Z, Rudd JH, Fayad ZA, Lehrer-Graiwer J, Korsgren M, Figueroa AL, Fredrickson J, Rubin B, Hoffmann U, Truong QA, Min JK, Baruch A, Nasir K, Nahrendorf M, Tawakol A. Emami H, et al. JACC Cardiovasc Imaging. 2015 Feb;8(2):121-30. doi: 10.1016/j.jcmg.2014.10.009. Epub 2015 Jan 7. JACC Cardiovasc Imaging. 2015. PMID: 25577441 Free PMC article. - Cryopreservation of primary human monocytes does not negatively affect their functionality or their ability to be labelled with radionuclides: basis for molecular imaging and cell therapy.
Pardali E, Schmitz T, Borgscheiper A, Iking J, Stegger L, Waltenberger J. Pardali E, et al. EJNMMI Res. 2016 Dec;6(1):77. doi: 10.1186/s13550-016-0232-5. Epub 2016 Oct 24. EJNMMI Res. 2016. PMID: 27778311 Free PMC article. - Positron emission tomography imaging for vascular inflammation evaluation in elderly subjects with different risk factors for cardiovascular diseases.
Khalil A, Orellana MR, Fulop T, Turcotte EE, Bentourkia M. Khalil A, et al. Am J Nucl Med Mol Imaging. 2014 Apr 25;4(3):283-92. eCollection 2014. Am J Nucl Med Mol Imaging. 2014. PMID: 24795842 Free PMC article. - Leukocytes Link Local and Systemic Inflammation in Ischemic Cardiovascular Disease: An Expanded "Cardiovascular Continuum".
Libby P, Nahrendorf M, Swirski FK. Libby P, et al. J Am Coll Cardiol. 2016 Mar 8;67(9):1091-1103. doi: 10.1016/j.jacc.2015.12.048. J Am Coll Cardiol. 2016. PMID: 26940931 Free PMC article. Review.
Publication types
MeSH terms
Substances
Grants and funding
- G0001237/MRC_/Medical Research Council/United Kingdom
- G0600986/MRC_/Medical Research Council/United Kingdom
- G9439390/MRC_/Medical Research Council/United Kingdom
- PG/09/083/27667/BHF_/British Heart Foundation/United Kingdom
LinkOut - more resources
Full Text Sources
Medical