Serum vitamin D and the risk of Parkinson disease - PubMed (original) (raw)
Serum vitamin D and the risk of Parkinson disease
Paul Knekt et al. Arch Neurol. 2010 Jul.
Abstract
Objective: To investigate whether serum vitamin D level predicts the risk of Parkinson disease.
Design: Cohort study.
Setting: The study was based on the Mini-Finland Health Survey, which was conducted from 1978 to 1980, with Parkinson disease occurrence follow-up through the end of 2007. During the 29-year follow-up period, 50 incident Parkinson disease cases occurred. Serum 25-hydroxyvitamin D level was determined from frozen samples stored at baseline. Estimates of the relationship between serum vitamin D concentration and Parkinson disease incidence were calculated using the Cox model.
Participants: Three thousand one hundred seventy-three men and women, aged 50 to 79 years and free of Parkinson disease at baseline. Main Outcome Measure Parkinson disease incidence.
Results: Individuals with higher serum vitamin D concentrations showed a reduced risk of Parkinson disease. The relative risk between the highest and lowest quartiles was 0.33 (95% confidence interval, 0.14-0.80) after adjustment for sex, age, marital status, education, alcohol consumption, leisure-time physical activity, smoking, body mass index, and month of blood draw.
Conclusions: The results are consistent with the suggestion that high vitamin D status provides protection against Parkinson disease. It cannot, however, be excluded that the finding is due to residual confounding and further studies are thus needed.
Comment in
- Beyond vitamin status: is there a role for vitamin d in Parkinson disease?
Evatt ML. Evatt ML. Arch Neurol. 2010 Jul;67(7):795-7. doi: 10.1001/archneurol.2010.123. Arch Neurol. 2010. PMID: 20625083 No abstract available. - Parkinson disease: Could sunlight offer protection from Parkinson disease?
McSharry C. McSharry C. Nat Rev Neurol. 2010 Sep;6(9):468. doi: 10.1038/nrneurol.2010.120. Nat Rev Neurol. 2010. PMID: 20836193 No abstract available. - Serum vitamin D and risk of Parkinson's disease.
Ross GW, Petrovitch H, Abbott RD. Ross GW, et al. Mov Disord. 2016 Jul;31(7):993-35. doi: 10.1002/mds.26639. Epub 2016 Apr 19. Mov Disord. 2016. PMID: 27091700 No abstract available.
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