Urotensin II, from fish to human - PubMed (original) (raw)
Review
Urotensin II, from fish to human
Hubert Vaudry et al. Ann N Y Acad Sci. 2010 Jul.
Abstract
The cyclic peptide urotensin II (UII) was originally isolated from the urophysis of teleost fish on the basis of its ability to contract intestinal smooth muscle. The UII peptide has subsequently been isolated from frog brain and, later on, the pre-proUII cDNA has been characterized in mammals, including humans. A UII paralog called urotensin II-related peptide (URP) has been identified in the rat brain. The UII and URP genes originate from the same ancestral gene as the somatostatin and cortistatin genes. In the central nervous system (CNS) of tetrapods, UII is expressed primarily in motoneurons of the brainstem and spinal cord. The biological actions of UII and URP are mediated through a G protein-coupled receptor, termed UT, that exhibits high sequence similarity with the somatostatin receptors. The UT gene is widely expressed in the CNS and in peripheral organs. Consistent with the broad distribution of UT, UII and URP exert a large array of behavioral effects and regulate endocrine, cardiovascular, renal, and immune functions.
Similar articles
- International Union of Basic and Clinical Pharmacology. XCII. Urotensin II, urotensin II-related peptide, and their receptor: from structure to function.
Vaudry H, Leprince J, Chatenet D, Fournier A, Lambert DG, Le Mével JC, Ohlstein EH, Schwertani A, Tostivint H, Vaudry D. Vaudry H, et al. Pharmacol Rev. 2015;67(1):214-58. doi: 10.1124/pr.114.009480. Pharmacol Rev. 2015. PMID: 25535277 Review. - Characterization of urotensin II, distribution of urotensin II, urotensin II-related peptide and UT receptor mRNAs in mouse: evidence of urotensin II at the neuromuscular junction.
Dubessy C, Cartier D, Lectez B, Bucharles C, Chartrel N, Montero-Hadjadje M, Bizet P, Chatenet D, Tostivint H, Scalbert E, Leprince J, Vaudry H, Jégou S, Lihrmann I. Dubessy C, et al. J Neurochem. 2008 Oct;107(2):361-74. doi: 10.1111/j.1471-4159.2008.05624.x. Epub 2008 Aug 14. J Neurochem. 2008. PMID: 18710417 - Liberation of urotensin II from the teleost urophysis: an historical overview.
Conlon JM. Conlon JM. Peptides. 2008 May;29(5):651-7. doi: 10.1016/j.peptides.2007.04.021. Epub 2007 May 6. Peptides. 2008. PMID: 17544546 Review. - New insight into the molecular evolution of the somatostatin family.
Tostivint H, Lihrmann I, Vaudry H. Tostivint H, et al. Mol Cell Endocrinol. 2008 May 14;286(1-2):5-17. doi: 10.1016/j.mce.2008.02.029. Epub 2008 Mar 6. Mol Cell Endocrinol. 2008. PMID: 18406049 Review. - Urotensin II-related peptide, the endogenous ligand for the urotensin II receptor in the rat brain.
Mori M, Fujino M. Mori M, et al. Peptides. 2004 Oct;25(10):1815-8. doi: 10.1016/j.peptides.2004.06.025. Peptides. 2004. PMID: 15476951 Review.
Cited by
- Irisin Ameliorates Muscle Atrophy by Inhibiting the Upregulation of the Ubiquitin‒Proteasome System in Chronic Kidney Disease.
Wang S, Pan Y, Pang Q, Zhang A. Wang S, et al. Calcif Tissue Int. 2024 Sep 16. doi: 10.1007/s00223-024-01283-4. Online ahead of print. Calcif Tissue Int. 2024. PMID: 39283327 - Urotensin II-related peptides, Urp1 and Urp2, control zebrafish spine morphology.
Bearce EA, Irons ZH, O'Hara-Smith JR, Kuhns CJ, Fisher SI, Crow WE, Grimes DT. Bearce EA, et al. Elife. 2022 Dec 1;11:e83883. doi: 10.7554/eLife.83883. Elife. 2022. PMID: 36453722 Free PMC article. - Reconstructing the Origins of the Somatostatin and Allatostatin-C Signaling Systems Using the Accelerated Evolution of Biodiverse Cone Snail Toxins.
Koch TL, Ramiro IBL, Flórez Salcedo P, Engholm E, Jensen KJ, Chase K, Olivera BM, Bjørn-Yoshimoto WE, Safavi-Hemami H. Koch TL, et al. Mol Biol Evol. 2022 Apr 10;39(4):msac075. doi: 10.1093/molbev/msac075. Mol Biol Evol. 2022. PMID: 35383850 Free PMC article. - The network map of urotensin-II mediated signaling pathway in physiological and pathological conditions.
Rex DAB, Suchitha GP, Palollathil A, Kanichery A, Prasad TSK, Dagamajalu S. Rex DAB, et al. J Cell Commun Signal. 2022 Dec;16(4):601-608. doi: 10.1007/s12079-022-00672-4. Epub 2022 Feb 16. J Cell Commun Signal. 2022. PMID: 35174439 Free PMC article. - Transcriptome Profiling of the Pacific Oyster Crassostrea gigas Visceral Ganglia over a Reproduction Cycle Identifies Novel Regulatory Peptides.
Réalis-Doyelle E, Schwartz J, Cabau C, Le Franc L, Bernay B, Rivière G, Klopp C, Favrel P. Réalis-Doyelle E, et al. Mar Drugs. 2021 Aug 7;19(8):452. doi: 10.3390/md19080452. Mar Drugs. 2021. PMID: 34436291 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Molecular Biology Databases