Associations between vitamin D receptor polymorphisms and susceptibility to rheumatoid arthritis and systemic lupus erythematosus: a meta-analysis - PubMed (original) (raw)
Meta-Analysis
. 2011 Aug;38(6):3643-51.
doi: 10.1007/s11033-010-0477-4. Epub 2010 Nov 26.
Affiliations
- PMID: 21110115
- DOI: 10.1007/s11033-010-0477-4
Meta-Analysis
Associations between vitamin D receptor polymorphisms and susceptibility to rheumatoid arthritis and systemic lupus erythematosus: a meta-analysis
Young Ho Lee et al. Mol Biol Rep. 2011 Aug.
Abstract
The aim of this study was to determine whether the vitamin D receptor (VDR) polymorphisms confer susceptibility to rheumatoid arthritis (RA) and systemic lupus erythematous (SLE). A meta-analysis was conducted on the associations between the BsmI, TaqI, FokI, and ApaI polymorphisms of VDR and RA or SLE using: (1) allele contrast, (2) the recessive model, (3) the dominant model, and (4) additive model. A total of ten studies, six RA and four SLE studies, were considered in the meta-analysis. Meta-analysis of the VDR BsmI and TaqI polymorphisms showed no association between RA in all subjects, or in European or Asian subjects. In contrast, meta-analysis of the F allele, the FF genotype, and the FF vs. the ff genotype of the FokI polymorphism showed significant associations with RA in Europeans. The overall OR of the association between the F allele and RA was 1.502 (95% CI=1.158-1.949, P=0.002). Meta-analysis of the B allele, BB+Bb genotype, and BB genotype (additive model) of the BsmI polymorphism showed significant associations with SLE and LN in Asians. The overall ORs of the associations between the B allele and SLE and LN were 3.584 (95% CI=1.407-9.130, P=0.007) and 3.652 (95% CI=1.347-9.902, P=0.011). This meta-analysis demonstrates that the VDR FokI polymorphism may confer susceptibility to RA in Europeans. Furthermore, associations were found between the VDR BsmI polymorphism and susceptibilities to SLE and LN in Asians.
Similar articles
- Vitamin D receptor FokI, TaqI, and ApaI polymorphisms and susceptibility to systemic lupus erythematosus: an updated meta-analysis.
Bae SC, Lee YH. Bae SC, et al. Clin Rheumatol. 2018 Jun;37(6):1529-1537. doi: 10.1007/s10067-018-4036-z. Epub 2018 Feb 21. Clin Rheumatol. 2018. PMID: 29468338 - Association between vitamin D receptor gene BsmI, FokI, ApaI and TaqI polymorphisms and the risk of systemic lupus erythematosus: a meta-analysis.
Mao S, Huang S. Mao S, et al. Rheumatol Int. 2014 Mar;34(3):381-8. doi: 10.1007/s00296-013-2898-6. Epub 2013 Nov 9. Rheumatol Int. 2014. PMID: 24212677 - Association of vitamin D receptor gene polymorphism with the risk of systemic lupus erythematosus.
Zhou TB, Jiang ZP, Lin ZJ, Su N. Zhou TB, et al. J Recept Signal Transduct Res. 2015 Feb;35(1):8-14. doi: 10.3109/10799893.2014.922577. Epub 2014 May 22. J Recept Signal Transduct Res. 2015. PMID: 24853028 - Association between VDR polymorphisms and rheumatoid arthritis disease: Systematic review and updated meta-analysis of case-control studies.
Tizaoui K, Hamzaoui K. Tizaoui K, et al. Immunobiology. 2015 Jun;220(6):807-16. doi: 10.1016/j.imbio.2014.12.013. Epub 2014 Dec 30. Immunobiology. 2015. PMID: 25577294 Review. - Vitamin D receptor FokI, BsmI, and TaqI polymorphisms and susceptibility to rheumatoid arthritis : A meta-analysis.
Song GG, Bae SC, Lee YH. Song GG, et al. Z Rheumatol. 2016 Apr;75(3):322-9. doi: 10.1007/s00393-015-1581-6. Z Rheumatol. 2016. PMID: 26358095 Review.
Cited by
- Genetic Risk of Rheumatoid Arthritis: A Case Control Study.
Ahmad HM, Zaki ZM, Mohamed AS, Ahmed AE. Ahmad HM, et al. Biochem Genet. 2024 Oct;62(5):3624-3641. doi: 10.1007/s10528-023-10648-7. Epub 2023 Dec 30. Biochem Genet. 2024. PMID: 38160213 Free PMC article. - Some genetic differences in patients with rheumatoid arthritis.
Ahmad HM, Zaki ZM, Mohamed AS, Ahmed AE. Ahmad HM, et al. BMC Res Notes. 2023 Oct 17;16(1):274. doi: 10.1186/s13104-023-06559-w. BMC Res Notes. 2023. PMID: 37849009 Free PMC article. - Immunomodulatory actions of vitamin D in various immune-related disorders: a comprehensive review.
Ghaseminejad-Raeini A, Ghaderi A, Sharafi A, Nematollahi-Sani B, Moossavi M, Derakhshani A, Sarab GA. Ghaseminejad-Raeini A, et al. Front Immunol. 2023 Jul 14;14:950465. doi: 10.3389/fimmu.2023.950465. eCollection 2023. Front Immunol. 2023. PMID: 37520529 Free PMC article. Review. - Strong Association between Vitamin D Receptor Gene and Severe Acute Respiratory Syndrome coronavirus 2 Infectious Variants.
Mamurova B, Akan G, Mogol E, Turgay A, Tuncel G, Evren EU, Evren H, Suer K, Sanlidag T, Ergoren MC. Mamurova B, et al. Glob Med Genet. 2023 Feb 16;10(1):27-33. doi: 10.1055/s-0043-1761924. eCollection 2023 Jan. Glob Med Genet. 2023. PMID: 36819669 Free PMC article. - Correlation Between Tic Disorders and Serum 25-Hydroxyvitamin D Levels in Chinese Children.
Wang S, Xu Q, Wang A, Yuan F, Luo X, Wang Y, Guo M, Zhang Y, Zhang W, Ji X, Ren Y, Chen Y. Wang S, et al. Front Pediatr. 2022 May 9;10:833371. doi: 10.3389/fped.2022.833371. eCollection 2022. Front Pediatr. 2022. PMID: 35615632 Free PMC article.
References
- Control Clin Trials. 1986 Sep;7(3):177-88 - PubMed
- FASEB J. 2001 Dec;15(14):2579-85 - PubMed
- Lupus. 2002;11(1):31-4 - PubMed
- Arthritis Res Ther. 2006;8(2):R48 - PubMed
- Int Arch Allergy Appl Immunol. 1985;77(4):396-404 - PubMed
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Medical