Meta-analysis of ADH1B and ALDH2 polymorphisms and esophageal cancer risk in China - PubMed (original) (raw)

Meta-Analysis

Meta-analysis of ADH1B and ALDH2 polymorphisms and esophageal cancer risk in China

Guo-Hong Zhang et al. World J Gastroenterol. 2010.

Abstract

Aim: To evaluate whether alcohol dehydrogenase-1B (ADH1B) His47Arg and aldehyde dehydrogenase-2 (ALDH2) Glu487Lys polymorphism is involved in the esophageal squamous cell carcinoma (ESCC) risk in Chinese Han population.

Methods: Seven studies of ADH1B and ALDH2 genotypes in Chinese Han population in 1450 cases and 2459 controls were included for meta-analysis. Stratified analyses were carried out to determine the gene-alcohol and gene-gene interaction with ESCC risk. Potential sources of heterogeneity between studies were explored, and publication bias was also evaluated.

Results: Individuals with ADH1B arginine (Arg)/Arg genotype showed 3.95-fold increased ESCC risk in the recessive genetic model [Arg/Arg vs Arg/histidine (His) + His/His: odds ratio (OR) = 3.95, 95% confidence interval (CI): 2.76-5.67]. Significant association was found in the dominant model for ALDH2 lysine (Lys) allele [glutamate (Glu)/Lys + Lys/Lys vs Glu/Glu: OR = 2.00, 95% CI: 1.54-2.61]. Compared with the non-alcoholics, Arg/Arg (OR = 25.20, 95% CI: 10.87-53.44) and Glu/Lys + Lys/Lys (OR = 21.47, 95% CI: 6.44-71.59) were found to interact with alcohol drinking to increase the ESCC risk. ADH1B Arg+ and ALDH2 Lys+ had a higher risk for ESCC (OR = 7.09, 95% CI: 2.16-23.33).

Conclusion: The genetic variations of ADH1B His47Arg and ALDH2 Glu487Lys are susceptible loci for ESCC in Chinese Han population and interact substantially with alcohol consumption. The individuals carrying both risky genotypes have a higher baseline risk of ESCC.

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Figures

Figure 1

Forest plot shows the odds ratios and confidence intervals of the association. A: Between arginine (Arg)/histidine (His) and His/His genotype of alcohol dehydrogenase-1B (ADH1B) His47Arg polymorphism; B: Between Arg/Arg and His/His genotype of ADH1B gene His47Arg polymorphism; C: Between glutamate (Glu)/lysine (Lys) and Gly/Glu genotype of aldehyde dehydrogenase-2 (ALDH2) Glu487Lys polymorphism; D: Between Lys/Lys and Glu/Glu genotype of ALDH2 Glu487Lys polymorphism. OR: Odds ratio; CI: Confidence interval.

Figure 2

Funnel plot of alcohol dehydrogenase-1B His47Arg (A) and aldehyde dehydrogenase-2 Glu487Lys (B) polymorphisms and esophageal squamous cell carcinoma risk for publication bias.

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Meta-analysis of ADH1B and ALDH2 polymorphisms and esophageal cancer risk in China - PubMed (original) (raw)