Genotype is a stronger determinant than sex of the mouse gut microbiota - PubMed (original) (raw)

Genotype is a stronger determinant than sex of the mouse gut microbiota

Amir Kovacs et al. Microb Ecol. 2011 Feb.

Abstract

The mammalian gut microbiota is considered to be determined mostly by diet, while the effect of genotype is still controversial. Here, we examined the effect of genotype on the gut microbiota in normal populations, exhibiting only natural polymorphisms, and evaluated this effect in comparison to the effect of sex. DNA fingerprinting approaches were used to profile the gut microbiota of eight different recombinant inbred mouse lines of the collaborative cross consortium, whose level of genetic diversity mimics that of a natural human population. Analyses based on automated ribosomal internal transcribed spacer analysis demonstrated significant higher similarity of the gut microbiota composition within mouse lines than between them or within same-gender groups. Thus, genetic background significantly impacts the microbiota composition and is a stronger determinant than gender. These findings imply that genetic polymorphisms help shape the intestinal microbiota of mammals and consequently could affect host susceptibility to diseases.

PubMed Disclaimer

Similar articles

• Host genetic and environmental effects on mouse intestinal microbiota.
  Campbell JH, Foster CM, Vishnivetskaya T, Campbell AG, Yang ZK, Wymore A, Palumbo AV, Chesler EJ, Podar M. Campbell JH, et al. ISME J. 2012 Nov;6(11):2033-44. doi: 10.1038/ismej.2012.54. Epub 2012 Jun 14. ISME J. 2012. PMID: 22695862 Free PMC article.
• Unravelling the effects of the environment and host genotype on the gut microbiome.
  Spor A, Koren O, Ley R. Spor A, et al. Nat Rev Microbiol. 2011 Apr;9(4):279-90. doi: 10.1038/nrmicro2540. Nat Rev Microbiol. 2011. PMID: 21407244 Review.
• Effects of vendor and genetic background on the composition of the fecal microbiota of inbred mice.
  Ericsson AC, Davis JW, Spollen W, Bivens N, Givan S, Hagan CE, McIntosh M, Franklin CL. Ericsson AC, et al. PLoS One. 2015 Feb 12;10(2):e0116704. doi: 10.1371/journal.pone.0116704. eCollection 2015. PLoS One. 2015. PMID: 25675094 Free PMC article.
• Gastrointestinal microbiota of wild and inbred individuals of two house mouse subspecies assessed using high-throughput parallel pyrosequencing.
  Kreisinger J, Cížková D, Vohánka J, Piálek J. Kreisinger J, et al. Mol Ecol. 2014 Oct;23(20):5048-60. doi: 10.1111/mec.12909. Epub 2014 Sep 29. Mol Ecol. 2014. PMID: 25204516
• Techniques used to characterize the gut microbiota: a guide for the clinician.
  Fraher MH, O'Toole PW, Quigley EM. Fraher MH, et al. Nat Rev Gastroenterol Hepatol. 2012 Mar 27;9(6):312-22. doi: 10.1038/nrgastro.2012.44. Nat Rev Gastroenterol Hepatol. 2012. PMID: 22450307 Review.

Cited by

• Mind-altering microorganisms: the impact of the gut microbiota on brain and behaviour.
  Cryan JF, Dinan TG. Cryan JF, et al. Nat Rev Neurosci. 2012 Oct;13(10):701-12. doi: 10.1038/nrn3346. Epub 2012 Sep 12. Nat Rev Neurosci. 2012. PMID: 22968153 Review.
• Host genetic and environmental effects on mouse intestinal microbiota.
  Campbell JH, Foster CM, Vishnivetskaya T, Campbell AG, Yang ZK, Wymore A, Palumbo AV, Chesler EJ, Podar M. Campbell JH, et al. ISME J. 2012 Nov;6(11):2033-44. doi: 10.1038/ismej.2012.54. Epub 2012 Jun 14. ISME J. 2012. PMID: 22695862 Free PMC article.
• Mulberry Leaf Supplements Effecting Anti-Inflammatory Genes and Improving Obesity in Elderly Overweight Dogs.
  Park M, Jaiswal V, Kim K, Chun J, Lee MJ, Shin JH, Lee HJ. Park M, et al. Int J Mol Sci. 2022 Dec 2;23(23):15215. doi: 10.3390/ijms232315215. Int J Mol Sci. 2022. PMID: 36499541 Free PMC article.
• Comparative study on intestinal microbiome composition and function in young and adult Hainan gibbons (Nomascus hainanus).
  Li Y, Bi Y, Yang L, Jin K. Li Y, et al. PeerJ. 2022 Jun 8;10:e13527. doi: 10.7717/peerj.13527. eCollection 2022. PeerJ. 2022. PMID: 35698614 Free PMC article.
• Different gut microbiome composition in obese Guizhou minipigs between female and castrated male.
  Yao G, Wu S, Zeng X, Zhao H, Wang G, Chen M, Qian N. Yao G, et al. Folia Microbiol (Praha). 2019 Nov;64(6):889-898. doi: 10.1007/s12223-019-00704-4. Epub 2019 Apr 22. Folia Microbiol (Praha). 2019. PMID: 31011890

References

1. 1. ISME J. 2007 Sep;1(5):403-18 - PubMed
2. 1. Proc Natl Acad Sci U S A. 2009 Jun 2;106(22):9016-20 - PubMed
3. 1. Appl Environ Microbiol. 2010 Apr;76(7):2086-90 - PubMed
4. 1. Nature. 2006 Dec 21;444(7122):1022-3 - PubMed
5. 1. Science. 1995 Aug 11;269(5225):773-5 - PubMed

Publication types

MeSH terms

Substances

LinkOut - more resources

• Full Text Sources

  • Springer