Distinctive anti-allergy properties of two probiotic bacterial strains in a mouse model of allergic poly-sensitization - PubMed (original) (raw)
. 2011 Feb 24;29(10):1981-90.
doi: 10.1016/j.vaccine.2010.12.101. Epub 2011 Jan 7.
Affiliations
- PMID: 21216308
- DOI: 10.1016/j.vaccine.2010.12.101
Distinctive anti-allergy properties of two probiotic bacterial strains in a mouse model of allergic poly-sensitization
Irma Schabussova et al. Vaccine. 2011.
Abstract
We compared the immunomodulatory properties of Bifidobacterium longum NCC 3001 and Lactobacillus paracasei NCC 2461 in a mouse model of poly-sensitization to birch and grass pollen allergens. Mucosal application of both strains at the time of sensitization and challenge led to significant suppression of airway inflammation and down-regulated allergen-specific immune responses. In contrast, in the mice treated with probiotics prior to sensitization and challenge, only B. longum displayed protective effects. Our findings stress that the choice of probiotic strain and the timing of the application are crucial for tolerance induction. Furthermore, this is the first demonstration of anti-allergic effects of probiotic bacteria in poly-sensitized mice.
Copyright © 2010 Elsevier Ltd. All rights reserved.
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