Meta-analyses of vitamin D intake, 25-hydroxyvitamin D status, vitamin D receptor polymorphisms, and colorectal cancer risk - PubMed (original) (raw)
. 2011 May;20(5):1003-16.
doi: 10.1158/1055-9965.EPI-10-1141. Epub 2011 Mar 4.
Affiliations
- PMID: 21378269
- DOI: 10.1158/1055-9965.EPI-10-1141
Free article
Meta-analyses of vitamin D intake, 25-hydroxyvitamin D status, vitamin D receptor polymorphisms, and colorectal cancer risk
Mathilde Touvier et al. Cancer Epidemiol Biomarkers Prev. 2011 May.
Free article
Abstract
Background: Our objective was to conduct a systematic review and meta-analysis of prospective studies on colorectal cancer (CRC) and vitamin D intake and 25-hydroxyvitamin D status, as part of the World Cancer Research Fund Continuous Update Project. We also aimed at conducting meta-analysis of all studies on CRC and vitamin D receptor (VDR) single-nucleotide polymorphisms.
Methods: Relevant studies were identified in PubMed (up to June 2010). Inclusion criteria were original and peer-reviewed publications with a prospective design (for studies on vitamin D intake or status). Random effects of dose-response meta-analyses were performed on cancer incidence.
Results: We observed inverse associations of CRC risk with dietary vitamin D [summary relative risk (RR) per 100 IU/day = 0.95, 95% CI: 0.93-0.98; 10 studies; range of intake (midpoints) = 39-719 IU/day] and serum/plasma 25-hydroxyvitamin D (RR per 100 IU/L = 0.96, 0.94-0.97; 6 studies; range = 200-1,800 IU/L), but not with total vitamin D (5 studies). Supplemental (2 studies; range = 0-600 IU/day) and total (4 studies; range = 79-732 IU/day) vitamin D intake and 25-hydroxyvitamin D status (6 studies; range = 200-1,800 IU/L) were inversely associated with colon cancer risk. We did not observe statistically significant associations between FokI, PolyA, TaqI, Cdx2, and ApaI VDR polymorphisms and CRC risk. The BsmI polymorphism was associated with a lower CRC risk (RR = 0.57, 0.36-0.89 for BB versus bb, 8 studies).
Conclusions: These meta-analyses support the evidence of an inverse association between vitamin D intake, 25-hydroxyvitamin D status, and the BsmI VDR polymorphism and CRC risk.
Impact: Improving vitamin D status could be potentially beneficial against CRC incidence.
©2011 AACR.
Similar articles
- Modification of the inverse association between dietary vitamin D intake and colorectal cancer risk by a FokI variant supports a chemoprotective action of Vitamin D intake mediated through VDR binding.
Theodoratou E, Farrington SM, Tenesa A, McNeill G, Cetnarskyj R, Barnetson RA, Porteous ME, Dunlop MG, Campbell H. Theodoratou E, et al. Int J Cancer. 2008 Nov 1;123(9):2170-9. doi: 10.1002/ijc.23769. Int J Cancer. 2008. PMID: 18709640 - Association of polymorphisms in the vitamin D receptor gene and serum 25-hydroxyvitamin D levels in children with autism spectrum disorder.
Coşkun S, Şimşek Ş, Camkurt MA, Çim A, Çelik SB. Coşkun S, et al. Gene. 2016 Aug 22;588(2):109-14. doi: 10.1016/j.gene.2016.05.004. Epub 2016 May 4. Gene. 2016. PMID: 27155524 - Vitamin D receptor polymorphisms, circulating vitamin D metabolites, and risk of prostate cancer in United States physicians.
Ma J, Stampfer MJ, Gann PH, Hough HL, Giovannucci E, Kelsey KT, Hennekens CH, Hunter DJ. Ma J, et al. Cancer Epidemiol Biomarkers Prev. 1998 May;7(5):385-90. Cancer Epidemiol Biomarkers Prev. 1998. PMID: 9610787 Clinical Trial. - Association between vitamin D and risk of colorectal cancer: a systematic review of prospective studies.
Ma Y, Zhang P, Wang F, Yang J, Liu Z, Qin H. Ma Y, et al. J Clin Oncol. 2011 Oct 1;29(28):3775-82. doi: 10.1200/JCO.2011.35.7566. Epub 2011 Aug 29. J Clin Oncol. 2011. PMID: 21876081 Review. - Association of vitamin D receptor gene polymorphism with the risk of lung cancer: a meta-analysis.
Zhong H, Zhou R, Feng Y, Zheng GX, Liang Y, Zhang JY, Qin XQ, Chen W, Wu JQ, Zhong YH. Zhong H, et al. J Recept Signal Transduct Res. 2014 Dec;34(6):500-5. doi: 10.3109/10799893.2014.921202. Epub 2014 May 29. J Recept Signal Transduct Res. 2014. PMID: 24875270 Review.
Cited by
- Umbrella Review on the Relationship between Vitamin D Levels and Cancer.
Schömann-Finck M, Reichrath J. Schömann-Finck M, et al. Nutrients. 2024 Aug 15;16(16):2720. doi: 10.3390/nu16162720. Nutrients. 2024. PMID: 39203855 Free PMC article. Review. - The Relationship between VDR Gene Polymorphisms Bsm1 and Apa1 with Breast Cancer Risk.
Mozaffarizadeh H, Mokarian F, Salehi M, Hakimian SMR, Moazam E, Amoozadehsamakoosh A, Hosseinzadeh M, Behnam M, Behjati M, Naseri A, Lotfi M, Tohidi F. Mozaffarizadeh H, et al. Glob Med Genet. 2024 Mar 4;11(1):69-75. doi: 10.1055/s-0044-1779040. eCollection 2024 Jan. Glob Med Genet. 2024. PMID: 38440355 Free PMC article. - Determinants of cancer incidence and mortality among people with vitamin D deficiency: an epidemiology study using a real-world population database.
Lai YC, Chen YH, Liang FW, Wu YC, Wang JJ, Lim SW, Ho CH. Lai YC, et al. Front Nutr. 2023 Dec 7;10:1294066. doi: 10.3389/fnut.2023.1294066. eCollection 2023. Front Nutr. 2023. PMID: 38130443 Free PMC article. - Sex Difference of Colon Adenoma Pathway and Colorectal Carcinogenesis.
Choi Y, Kim N. Choi Y, et al. World J Mens Health. 2024 Apr;42(2):256-282. doi: 10.5534/wjmh.230085. Epub 2023 Aug 29. World J Mens Health. 2024. PMID: 37652658 Free PMC article. Review. - Pre-diagnostic intake of vitamin D and incidence of colorectal cancer by anatomical subsites: the Norwegian Women and Cancer Cohort Study (NOWAC).
Paulsen EM, Rylander C, Brustad M, Jensen TE. Paulsen EM, et al. Br J Nutr. 2023 Sep 28;130(6):1047-1055. doi: 10.1017/S0007114523000077. Epub 2023 Jan 9. Br J Nutr. 2023. PMID: 36620946 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Medical