The impact of a nationwide antibiotic restriction program on antibiotic usage and resistance against nosocomial pathogens in Turkey - PubMed (original) (raw)

Multicenter Study

The impact of a nationwide antibiotic restriction program on antibiotic usage and resistance against nosocomial pathogens in Turkey

Adalet Altunsoy et al. Int J Med Sci. 2011.

Abstract

Purpose: Antimicrobial resistance among microorganisms is a global concern. In 2003, a nationwide antibiotic restriction program (NARP) was released in Turkey. In this study we evaluated the effect of NARP on antibiotic consumption, antimicrobial resistance, and cost.

Materials and methods: The data obtained from all of the four university hospitals, and one referral tertiary-care educational state hospital in Ankara. Antimicrobial resistance profiles of 14,233 selected microorganisms all grown in blood cultures and antibiotic consumption from 2001 to 2005 were analyzed retrospectively.

Results: A negative correlation was observed between the ceftriaxone consumption and the prevalence of ceftriaxone resistant E.coli and Klebsiella spp. (rho:-0.395, p:0.332 and rho:-0.627, p:0.037, respectively). The decreased usage of carbapenems was correlated with decreased carbapenems-resistant Pseudomonas spp. and Acinetobacter spp (rho:0.155, p:0.712 and rho:0.180, p:0.668, respectively for imipenem). Methicillin resistance rates of S.aureus were decreased from 44% to 41%. After two years of NARP 5,389,155.82 USD saving occurred.

Conclusion: NARP is effective in lowering the costs and antibiotic resistance.

Keywords: Antibiotic consumption; antimicrobial resistance surveillance; restriction policy..

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Conflict of interest statement

Conflict of Interest: The authors have declared that no conflict of interest exists.

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References

1. Fishman ON. Antimicrobial Stewardship. Am J Med. 2006;119(6A):53–61. - PubMed
1. Polk ER, Fishman ON. Antimicrobial Management: Cost and Resistance. In: Mandell GL, Bennett JE, Dolin R, editors. Principles and Practice of Infectious Diseases, 6th ed. Philadelphia: Churchill Livingstone Inc; 2005. pp. 611–619.
1. McGowan JEJr. Economic Impact of Antimicrobial Resistance. Emerg Infect Dis. 2001;7:286–292. - PMC - PubMed
1. Polk R. Optimal Use of Modern Antibiotics: Emerging Trends. Clin Infect Dis. 1999;29:264–274. - PubMed
1. Bassetti M, Di Biagio A, Rebesco B, Amalfitano ME, Topal J, Bassetti D. The effect of formulary restriction in the use of antibiotics in Italian hospital. Eur J Clin Pharmacol. 2001;57:529–534. - PubMed

The impact of a nationwide antibiotic restriction program on antibiotic usage and resistance against nosocomial pathogens in Turkey - PubMed (original) (raw)