Effects of genetic variants in ADCY5, GIPR, GCKR and VPS13C on early impairment of glucose and insulin metabolism in children - PubMed (original) (raw)

• Genetic variation in GIPR influences the glucose and insulin responses to an oral glucose challenge.
  Saxena R, Hivert MF, Langenberg C, Tanaka T, Pankow JS, Vollenweider P, Lyssenko V, Bouatia-Naji N, Dupuis J, Jackson AU, Kao WH, Li M, Glazer NL, Manning AK, Luan J, Stringham HM, Prokopenko I, Johnson T, Grarup N, Boesgaard TW, Lecoeur C, Shrader P, O'Connell J, Ingelsson E, Couper DJ, Rice K, Song K, Andreasen CH, Dina C, Köttgen A, Le Bacquer O, Pattou F, Taneera J, Steinthorsdottir V, Rybin D, Ardlie K, Sampson M, Qi L, van Hoek M, Weedon MN, Aulchenko YS, Voight BF, Grallert H, Balkau B, Bergman RN, Bielinski SJ, Bonnefond A, Bonnycastle LL, Borch-Johnsen K, Böttcher Y, Brunner E, Buchanan TA, Bumpstead SJ, Cavalcanti-Proença C, Charpentier G, Chen YD, Chines PS, Collins FS, Cornelis M, J Crawford G, Delplanque J, Doney A, Egan JM, Erdos MR, Firmann M, Forouhi NG, Fox CS, Goodarzi MO, Graessler J, Hingorani A, Isomaa B, Jørgensen T, Kivimaki M, Kovacs P, Krohn K, Kumari M, Lauritzen T, Lévy-Marchal C, Mayor V, McAteer JB, Meyre D, Mitchell BD, Mohlke KL, Morken MA, Narisu N, Palmer CN, Pakyz R, Pascoe L, Payne F, Pearson D, Rathmann W, Sandbaek A, Sayer AA, Scott LJ, Sharp SJ, Sijbrands E, Singleton A, Siscovick DS, Smith NL, Sparsø T, Swift AJ, Syddall H, Thorleifsson G, Tö… See abstract for full author list ➔ Saxena R, et al. Nat Genet. 2010 Feb;42(2):142-8. doi: 10.1038/ng.521. Epub 2010 Jan 17. Nat Genet. 2010. PMID: 20081857 Free PMC article.
• Genetic variants in GCKR, GIPR, ADCY5 and VPS13C and the risk of severe sulfonylurea-induced hypoglycaemia in patients with type 2 diabetes.
  Holstein JD, Patzer O, Körner A, Stumvoll M, Kovacs P, Holstein A. Holstein JD, et al. Exp Clin Endocrinol Diabetes. 2013 Jan;121(1):54-7. doi: 10.1055/s-0032-1321834. Epub 2012 Sep 6. Exp Clin Endocrinol Diabetes. 2013. PMID: 22956255 Clinical Trial.
• Glucose-raising genetic variants in MADD and ADCY5 impair conversion of proinsulin to insulin.
  Wagner R, Dudziak K, Herzberg-Schäfer SA, Machicao F, Stefan N, Staiger H, Häring HU, Fritsche A. Wagner R, et al. PLoS One. 2011;6(8):e23639. doi: 10.1371/journal.pone.0023639. Epub 2011 Aug 22. PLoS One. 2011. PMID: 21887289 Free PMC article.
• Genetic origins of low birth weight.
  Yaghootkar H, Freathy RM. Yaghootkar H, et al. Curr Opin Clin Nutr Metab Care. 2012 May;15(3):258-64. doi: 10.1097/MCO.0b013e328351f543. Curr Opin Clin Nutr Metab Care. 2012. PMID: 22406741 Review.
• Glucose-dependent insulinotropic polypeptide (GIP) receptor antagonists as anti-diabetic agents.
  Gasbjerg LS, Gabe MBN, Hartmann B, Christensen MB, Knop FK, Holst JJ, Rosenkilde MM. Gasbjerg LS, et al. Peptides. 2018 Feb;100:173-181. doi: 10.1016/j.peptides.2017.11.021. Peptides. 2018. PMID: 29412817 Review.