Oral contraceptive use: impact on folate, vitamin B₆, and vitamin B₁₂ status - PubMed (original) (raw)
Review
Oral contraceptive use: impact on folate, vitamin B₆, and vitamin B₁₂ status
Stephanie M C Wilson et al. Nutr Rev. 2011 Oct.
Abstract
Since many unplanned pregnancies occur while women are using oral contraceptives (OCs), it is important to understand the potential impact of these drugs on folate, vitamin B₆ , and vitamin B₁₂ status. Although a number of early studies concluded that OCs negatively impact folate status, the majority of these studies were conducted when the estrogen content of OCs was much higher. In addition, the interpretation of findings from many of these studies is problematic since no controls were included for potentially confounding factors. The presently available data do not support a conclusion that currently used OCs negatively impact folate status. In regard to vitamin B₆ , however, existing population-based data do provide evidence that current low-dose OCs may negatively impact vitamin B₆ status. The observed depression in plasma pyridoxal 5'-phosphate concentrations in OC users may reflect decreased body reserves of the vitamin, which could put women who discontinue OCs and become pregnant at risk for vitamin B₆ inadequacy during pregnancy. Functional indicators of vitamin B₁₂ status are not significantly impacted by OC use. Definitive conclusions, however, await further investigations.
© 2011 International Life Sciences Institute.
Similar articles
- Unintended pregnancies and use, misuse and discontinuation of oral contraceptives.
Rosenberg MJ, Waugh MS, Long S. Rosenberg MJ, et al. J Reprod Med. 1995 May;40(5):355-60. J Reprod Med. 1995. PMID: 7608875 - Oral contraceptives did not affect biochemical folate indexes and homocysteine concentrations in adolescent females.
Green TJ, Houghton LA, Donovan U, Gibson RS, O'Connor DL. Green TJ, et al. J Am Diet Assoc. 1998 Jan;98(1):49-55. doi: 10.1016/S0002-8223(98)00014-5. J Am Diet Assoc. 1998. PMID: 9434651 - Nutritional effects of oral contraceptive use: a review.
Webb JL. Webb JL. J Reprod Med. 1980 Oct;25(4):150-6. J Reprod Med. 1980. PMID: 7001015 Review. - Drugs and vitamin B12 and folate metabolism.
Lindenbaum J. Lindenbaum J. Curr Concepts Nutr. 1983;12:73-87. Curr Concepts Nutr. 1983. PMID: 6133702 Review. - The risk of folate and vitamin B(12) deficiencies associated with hyperhomocysteinemia among pregnant women.
Park H, Kim YJ, Ha EH, Kim KN, Chang N. Park H, et al. Am J Perinatol. 2004 Nov;21(8):469-75. doi: 10.1055/s-2004-835964. Am J Perinatol. 2004. PMID: 15580543
Cited by
- Molecular Mechanisms Provide a Landscape for Biomarker Selection for Schizophrenia and Schizoaffective Psychosis.
Fryar-Williams S, Strobel J, Clements P. Fryar-Williams S, et al. Int J Mol Sci. 2023 Oct 18;24(20):15296. doi: 10.3390/ijms242015296. Int J Mol Sci. 2023. PMID: 37894974 Free PMC article. Review. - Metabolomic Profiling of Hormonal Contraceptive Use in Young Females Using a Commercially Available LC-MS/MS Kit.
Grobler T, Opperman M, Bester J, Swanepoel AC, du Preez I. Grobler T, et al. Metabolites. 2023 Oct 18;13(10):1092. doi: 10.3390/metabo13101092. Metabolites. 2023. PMID: 37887417 Free PMC article. - Striatal dopamine synthesis and cognitive flexibility differ between hormonal contraceptive users and nonusers.
Taylor CM, Furman DJ, Berry AS, White RL 3rd, Jagust WJ, D'Esposito M, Jacobs EG. Taylor CM, et al. Cereb Cortex. 2023 Jun 20;33(13):8485-8495. doi: 10.1093/cercor/bhad134. Cereb Cortex. 2023. PMID: 37160338 Free PMC article. - Impact of lifestyle factors on dietary vitamin B6 intake and plasma pyridoxal 5'-phosphate level in UK adults: National Diet and Nutrition Survey Rolling Programme (NDNS) (2008-2017).
Alsaeedi A, Welham S, Rose P. Alsaeedi A, et al. Br J Nutr. 2023 Oct 28;130(8):1403-1415. doi: 10.1017/S0007114523000417. Epub 2023 Feb 15. Br J Nutr. 2023. PMID: 36789783 Free PMC article. - Sex Differences Across the Life Course: A Focus On Unique Nutritional and Health Considerations among Women.
Bailey RL, Dog TL, Smith-Ryan AE, Das SK, Baker FC, Madak-Erdogan Z, Hammond BR, Sesso HD, Eapen A, Mitmesser SH, Wong A, Nguyen H. Bailey RL, et al. J Nutr. 2022 Jul 6;152(7):1597-1610. doi: 10.1093/jn/nxac059. J Nutr. 2022. PMID: 35294009 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Medical