Recognizing the musculoskeletal manifestations of vitamin D deficiency - PubMed (original) (raw)

. 2009 Oct;26(10):389-396.

Affiliations

• PMID: 21984863
• PMCID: PMC3188408

Recognizing the musculoskeletal manifestations of vitamin D deficiency

Andrea N Jones et al. J Musculoskelet Med. 2009 Oct.

Abstract

A disruption in any part of the vitamin D physiological pathway can result in vitamin D deficiency, which may lead to bone pain, muscle weakness, falls, low bone mass, and fractures. Recognizing the signs and symptoms helps physicians make a proper diagnosis and prescribe appropriate treatment. Physicians should suspect osteomalacia in patients who have prolonged vitamin D deficiency, a low serum calcium level, or a low serum phosphorus level. Patients with cystic fibrosis are at increased risk for deficiencies in fat-soluble vitamins, including vitamin D. Secondary hyperparathyroidism can develop in patients with chronic kidney disease as a result of low 25-hydroxyvitamin D levels or impaired conversion to 1,25-dihydroxyvitamin D. Patients may experience abnormal vitamin D metabolism as a result of taking anticonvulsants and other medications.

PubMed Disclaimer

Figures

Figure

Pelvis (A) and humerus (B) x-ray films obtained for a patient with osteomalacia show Looser zones (arrows), which are radiolucent areas that occur at right angles to the bone cortex. They represent incomplete fractures resulting from osteomalacia.

Similar articles

• Vitamin D metabolism and osteomalacia in cystic fibrosis.
  Friedman HZ, Langman CB, Favus MJ. Friedman HZ, et al. Gastroenterology. 1985 Mar;88(3):808-13. doi: 10.1016/0016-5085(85)90156-8. Gastroenterology. 1985. PMID: 3871414
• Posterior urethral valves: Metabolic consequences in a cohort of patients.
  Sarhan O, Nakshabandi Z, Alghanbar M, Alotay A, Sherif I, Whitehead C, El-Husseini A. Sarhan O, et al. J Pediatr Urol. 2015 Aug;11(4):216.e1-6. doi: 10.1016/j.jpurol.2015.04.022. Epub 2015 Jun 4. J Pediatr Urol. 2015. PMID: 26096436
• Bone mineral metabolism and its relationship to kidney disease in a residential care home population: a cross-sectional study.
  Carter JL, O'Riordan SE, Eaglestone GL, Delaney MP, Lamb EJ. Carter JL, et al. Nephrol Dial Transplant. 2008 Nov;23(11):3554-65. doi: 10.1093/ndt/gfn302. Epub 2008 Jun 10. Nephrol Dial Transplant. 2008. PMID: 18544628
• The metabolism and functions of vitamin D.
  DeLuca HF. DeLuca HF. Adv Exp Med Biol. 1986;196:361-75. doi: 10.1007/978-1-4684-5101-6_24. Adv Exp Med Biol. 1986. PMID: 3012979 Review.
• Crucial Role of Vitamin D in the Musculoskeletal System.
  Wintermeyer E, Ihle C, Ehnert S, Stöckle U, Ochs G, de Zwart P, Flesch I, Bahrs C, Nussler AK. Wintermeyer E, et al. Nutrients. 2016 Jun 1;8(6):319. doi: 10.3390/nu8060319. Nutrients. 2016. PMID: 27258303 Free PMC article. Review.

Cited by

• Low serum 25-hydroxyvitamin D level is associated with obesity and atherogenesis in adolescent boys.
  Naganuma J, Koyama S, Arisaka O, Yoshihara S. Naganuma J, et al. Ann Pediatr Endocrinol Metab. 2022 Mar;27(1):30-36. doi: 10.6065/apem.2142112.056. Epub 2021 Oct 17. Ann Pediatr Endocrinol Metab. 2022. PMID: 34670071 Free PMC article.
• Significant association among growing pains, vitamin D supplementation, and bone mineral status: results from a pilot cohort study.
  Morandi G, Maines E, Piona C, Monti E, Sandri M, Gaudino R, Boner A, Antoniazzi F. Morandi G, et al. J Bone Miner Metab. 2015 Mar;33(2):201-6. doi: 10.1007/s00774-014-0579-5. Epub 2014 Mar 15. J Bone Miner Metab. 2015. PMID: 24633492
• Association between neurological and rheumatological manifestations in vitamin D deficiency and vitamin D levels.
  A Qari F, A Nasser T. A Qari F, et al. Pak J Med Sci. 2013 May;29(3):735-9. doi: 10.12669/pjms.293.3447. Pak J Med Sci. 2013. PMID: 24353618 Free PMC article.

References

1. 1. Holick MF. Vitamin D deficiency. N Engl J Med. 2007;357:266–281. - PubMed
2. 1. Looker AC, Pfeiffer CM, Lacher DA, et al. Serum 25-hydroxyvitamin D status of the US population: 1988–1994 compared to 2000–2004. Am J Clin Nutr. 2008;88:1519–1527. - PMC - PubMed
3. 1. Reginato AJ, Coquia JA. Musculoskeletal manifestations of osteomalacia and rickets. Best Pract Res Clin Rheumatol. 2003;17:1063–1080. - PubMed
4. 1. Bingham CT, Fitzpatrick LA. Noninvasive testing in the diagnosis of osteomalacia. Am J Med. 1993;95:519–523. - PubMed
5. 1. Bhambri R, Naik V, Malhotra N, et al. Changes in bone mineral density following treatment of osteomalacia. J Clin Densitom. 2006;9:120–127. - PubMed

Grants and funding

• UL1 RR025011-03/RR/NCRR NIH HHS/United States
• UL1 RR025011/RR/NCRR NIH HHS/United States
• UL1 RR025011-02/RR/NCRR NIH HHS/United States
• UL1 RR025011-05/RR/NCRR NIH HHS/United States
• UL1 RR025011-01/RR/NCRR NIH HHS/United States
• UL1 RR025011-04/RR/NCRR NIH HHS/United States

LinkOut - more resources

• Full Text Sources

  • Europe PubMed Central
  • PubMed Central