Autonomic nervous system and lipid metabolism: findings in anxious-depressive spectrum and eating disorders - PubMed (original) (raw)

Autonomic nervous system and lipid metabolism: findings in anxious-depressive spectrum and eating disorders

Elisabetta Pistorio et al. Lipids Health Dis. 2011.

Abstract

Objective: To correlate lipid metabolism and autonomic dysfunction with anxious-depressive spectrum and eating disorders. To propose the lipid index (LI) as a new possible biomarker.

Methods: 95 patients and 60 controls were enrolled from the University Psychiatry Unit of Catania and from general practitioners (GPs). The patients were divided into four pathological groups: Anxiety, Depression, Anxious-Depressive Disorder and Eating Disorders [Diagnostic and Statistical Manual of Mental Disorders Fourth Edition Text Revision (DSM-IV-TR) official/appendix criteria]. The levels of the cholesterol, triglycerides and apolipoproteins A and B were determined. The LI, for each subject, was obtained through a mathematical operation on the values of the cholesterol and triglycerides levels compared with the maximum cut-off of the general population. The autonomic functioning was tested with Ewing battery tests. Particularly, the correlation between heart rate variability (HRV) and lipid metabolism has been investigated.

Results: Pathological and control groups, compared among each other, presented some peculiarities in the lipid metabolism and the autonomic dysfunction scores. In addition, a statistically significant correlation has been found between HRV and lipid metabolism.

Conclusions: Lipid metabolism and autonomic functioning seem to be related to the discussed psychiatric disorders. LI, in addition, could represent a new possible biomarker to be considered.

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Figures

Figure 1

Figure 1

(Distribution of pathological groups)-Legend: the percentages of the pathological groups within the sample are shown.

Figure 2

Figure 2

(Ewing score of patients)-Legend: the distribution of the different levels of the autonomic dysfunctions within the whole pathological sample is shown in percentage.

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References

    1. Bajwa WK, Asnis GM, Sanderson WC, Irfan A, van Praag HM. High cholesterol levels in patients with panic disorder. Am J Psychiatry. 1992;149:376–378. - PubMed
    1. Rafter D. Biochemical markers of anxiety and depression. Psychiatry Res. 2001;103:93–96. doi: 10.1016/S0165-1781(01)00251-7. - DOI - PubMed
    1. Sevincok L, Buyukozturk A, Dereboy F. Serum lipid concentrations in patients with comorbid generalized anxiety disorder and major depressive disorder. Can J Psychiatry. 2001;46:68–71. - PubMed
    1. Agargun MY, Dulger H, Inci R, Kara H, Ozer OA, Sekereğlu MR, Besiroglu L. Serum concentrations in obsessive-compulsive disorder patients with and without panic attacks. Can J Psychiatry. 2004;49:776–778. - PubMed
    1. Shin JY, Suls J, Martin R. Are Cholesterol and Depression Inversely Related? A meta-analysis of the association between two cardiac risk factors. Ann Behav Med. 2008;36:33–43. doi: 10.1007/s12160-008-9045-8. - DOI - PubMed

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