Antioxidant and anti-inflammatory properties of Capsicum baccatum: from traditional use to scientific approach - PubMed (original) (raw)
. 2012 Jan 6;139(1):228-33.
doi: 10.1016/j.jep.2011.11.005. Epub 2011 Nov 9.
Affiliations
- PMID: 22100562
- DOI: 10.1016/j.jep.2011.11.005
Free article
Antioxidant and anti-inflammatory properties of Capsicum baccatum: from traditional use to scientific approach
Aline Rigon Zimmer et al. J Ethnopharmacol. 2012.
Free article
Abstract
Ethnopharmacological relevance: Peppers from Capsicum species (Solanaceae) are native to Central and South America, and are commonly used as food and also for a broad variety of medicinal applications.
Aim of the study: The red pepper Capsicum baccatum var. pendulum is widely consumed in Brazil, but there are few reports in the literature of studies on its chemical composition and biological properties. In this study the antioxidant and anti-inflammatory activities of Capsicum baccatum were evaluated and the total phenolic compounds and flavonoid contents were determined.
Materials and methods: The antioxidant property was assayed by scavenging abilities using DPPH and the anti-inflammatory activity was tested through the carrageenan-induced pleurisy model in mice. The total phenolic compounds and flavonoid contents were determined spectrophotometrically.
Results: The ethanolic and butanol extracts (200mg/kg, p.o.) presented a significant anti-inflammatory activity toward carrageenan-induced pleurisy model in mice in comparison to dexamethasone (0.5mg/kg, s.c.). Among the parameters evaluated, the treatment with these samples inhibited leukocyte migration and reduced the formation of exudate. The contents of flavonoids and total phenolic compounds could be correlated with the antioxidant and anti-inflammatory activities observed for Capsicum baccatum.
Conclusions: Our findings suggest that Capsicum baccatum contains potential antioxidant and anti-inflammatory compounds which could be tested as drug candidates against oxidative and inflammation-related pathological processes in medicinal chemistry studies.
Copyright © 2011 Elsevier Ireland Ltd. All rights reserved.
Similar articles
- Anti-inflammatory effects of red pepper (Capsicum baccatum) on carrageenan- and antigen-induced inflammation.
Spiller F, Alves MK, Vieira SM, Carvalho TA, Leite CE, Lunardelli A, Poloni JA, Cunha FQ, de Oliveira JR. Spiller F, et al. J Pharm Pharmacol. 2008 Apr;60(4):473-8. doi: 10.1211/jpp.60.4.0010. J Pharm Pharmacol. 2008. PMID: 18380920 - Anti-inflammatory, analgesic, and antioxidant activities of Pisonia aculeata: folk medicinal use to scientific approach.
Sen S, Chakraborty R, Rekha B, Revathi D, Ayyanna SC, Hemalatha G, Kumar Reddy GA, Hyndavi S, Ikhyatha Babu PJ, Prakash PR, Sridhar C. Sen S, et al. Pharm Biol. 2013 Apr;51(4):426-32. doi: 10.3109/13880209.2012.738331. Epub 2013 Jan 22. Pharm Biol. 2013. PMID: 23336600 - Anti-inflammatory, antioxidant and anti-Mycobacterium tuberculosis activity of viridiflorol: The major constituent of Allophylus edulis (A. St.-Hil., A. Juss. & Cambess.) Radlk.
Trevizan LNF, Nascimento KFD, Santos JA, Kassuya CAL, Cardoso CAL, Vieira MDC, Moreira FMF, Croda J, Formagio ASN. Trevizan LNF, et al. J Ethnopharmacol. 2016 Nov 4;192:510-515. doi: 10.1016/j.jep.2016.08.053. Epub 2016 Sep 6. J Ethnopharmacol. 2016. PMID: 27612433 - Biological Properties, Bioactive Constituents, and Pharmacokinetics of Some Capsicum spp. and Capsaicinoids.
Batiha GE, Alqahtani A, Ojo OA, Shaheen HM, Wasef L, Elzeiny M, Ismail M, Shalaby M, Murata T, Zaragoza-Bastida A, Rivero-Perez N, Magdy Beshbishy A, Kasozi KI, Jeandet P, Hetta HF. Batiha GE, et al. Int J Mol Sci. 2020 Jul 22;21(15):5179. doi: 10.3390/ijms21155179. Int J Mol Sci. 2020. PMID: 32707790 Free PMC article. Review.
Cited by
- Curcumin and capsaicin regulate apoptosis and alleviate intestinal inflammation induced by Clostridioides difficile in vitro.
Azimirad M, Noori M, Azimirad F, Gholami F, Naseri K, Yadegar A, Asadzadeh Aghdaei H, Zali MR. Azimirad M, et al. Ann Clin Microbiol Antimicrob. 2022 Sep 26;21(1):41. doi: 10.1186/s12941-022-00533-3. Ann Clin Microbiol Antimicrob. 2022. PMID: 36155114 Free PMC article. - Capsicum Waste as a Sustainable Source of Capsaicinoids for Metabolic Diseases.
Yasin M, Li L, Donovan-Mak M, Chen ZH, Panchal SK. Yasin M, et al. Foods. 2023 Feb 20;12(4):907. doi: 10.3390/foods12040907. Foods. 2023. PMID: 36832982 Free PMC article. Review. - Ethereal Extract of Pepper: Preventing Atherosclerosis and Left Ventricle Remodeling in LDL Receptor Knockout Mice.
Dos Santos L, Maciel LO, Gracia EKI, Soares EA, Sarto DAQS, Barauna VG, Estrela HFG, Rocha CM, Carvalho MDGS, Boas BMV, Garcia JAD. Dos Santos L, et al. Prev Nutr Food Sci. 2021 Mar 31;26(1):51-57. doi: 10.3746/pnf.2021.26.1.51. Prev Nutr Food Sci. 2021. PMID: 33859959 Free PMC article. - Antioxidant and anti-inflammatory activities of barettin.
Lind KF, Hansen E, Østerud B, Eilertsen KE, Bayer A, Engqvist M, Leszczak K, Jørgensen TØ, Andersen JH. Lind KF, et al. Mar Drugs. 2013 Jul 22;11(7):2655-66. doi: 10.3390/md11072655. Mar Drugs. 2013. PMID: 23880935 Free PMC article. - Interaction of smoking and spicy habits modifies the risk of erectile dysfunction.
Li X, Li Y, Xiang B, Liu L, Zhang C, Li Z, Li D. Li X, et al. Transl Androl Urol. 2024 Jul 31;13(7):1206-1218. doi: 10.21037/tau-24-26. Epub 2024 Jul 15. Transl Androl Urol. 2024. PMID: 39100824 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical
Research Materials