The influence of milk oligosaccharides on microbiota of infants: opportunities for formulas - PubMed (original) (raw)

Review

The influence of milk oligosaccharides on microbiota of infants: opportunities for formulas

Maciej Chichlowski et al. Annu Rev Food Sci Technol. 2011.

Abstract

In addition to a nutritive role, human milk also guides the development of a protective intestinal microbiota in the infant. Human milk possesses an overabundance of complex oligosaccharides that are indigestible by the infant yet are consumed by microbial populations in the developing intestine. These oligosaccharides are believed to facilitate enrichment of a healthy infant gastrointestinal microbiota, often associated with bifidobacteria. Advances in glycomics have enabled precise determination of milk glycan structures as well as identification of the specific glycans consumed by various gut microbes. Furthermore, genomic analysis of bifidobacteria from infants has revealed specific genetic loci related to milk oligosaccharide import and processing, suggesting coevolution between the human host, milk glycans, and the microbes they enrich. This review discusses the current understanding of how human milk oligosaccharides interact with the infant microbiota and examines the opportunities for translating this knowledge to improve the functionality of infant formulas.

PubMed Disclaimer

Figures

Figure 1

43 Kb gene cluster in B. infantis ATCC15697 containing glycosyl hydrolases and transport-related genes (TRG) required for importing and metabolizing HMOs. SBP: solute binding protein, M: major facilitator superfamily, P: ABC transporter permease component, and A: ABC transporter ATPase subunit. Adapted from Sela et al. (2008).

Cited by

Functional similarities between pigeon 'milk' and mammalian milk: induction of immune gene expression and modification of the microbiota.
Gillespie MJ, Stanley D, Chen H, Donald JA, Nicholas KR, Moore RJ, Crowley TM. Gillespie MJ, et al. PLoS One. 2012;7(10):e48363. doi: 10.1371/journal.pone.0048363. Epub 2012 Oct 26. PLoS One. 2012. PMID: 23110233 Free PMC article.
Glucocorticoid receptor-PPARα axis in fetal mouse liver prepares neonates for milk lipid catabolism.
Rando G, Tan CK, Khaled N, Montagner A, Leuenberger N, Bertrand-Michel J, Paramalingam E, Guillou H, Wahli W. Rando G, et al. Elife. 2016 Jul 1;5:e11853. doi: 10.7554/eLife.11853. Elife. 2016. PMID: 27367842 Free PMC article.
Bifidobacterium longum Subspecies infantis (B. infantis) in Pediatric Nutrition: Current State of Knowledge.
Chichlowski M, Shah N, Wampler JL, Wu SS, Vanderhoof JA. Chichlowski M, et al. Nutrients. 2020 May 28;12(6):1581. doi: 10.3390/nu12061581. Nutrients. 2020. PMID: 32481558 Free PMC article. Review.
Early development of the gut microbiota and immune health.
Francino MP. Francino MP. Pathogens. 2014 Sep 24;3(3):769-90. doi: 10.3390/pathogens3030769. Pathogens. 2014. PMID: 25438024 Free PMC article. Review.
Bifidobacterium mongoliense genome seems particularly adapted to milk oligosaccharide digestion leading to production of antivirulent metabolites.
Bondue P, Milani C, Arnould E, Ventura M, Daube G, LaPointe G, Delcenserie V. Bondue P, et al. BMC Microbiol. 2020 May 7;20(1):111. doi: 10.1186/s12866-020-01804-9. BMC Microbiol. 2020. PMID: 32380943 Free PMC article.

References

1. Adlerberth I, Wold AE. 2009. Establishment of the gut microbiota in Western infants. Acta Paediatr. 98:229–38 - PubMed
1. Albrecht S, Schols HA, van den Heuvel EG, Voragen AG, Gruppen H. 2010. CE-LIF-MS n profiling of oligosaccharides in human milk and feces of breast-fed babies. Electrophoresis. 31(7):1264–73 - PubMed
1. Andersson B, Porras O, Hanson LA, Lagergård T, Svanborg-Edén C. 1986. Inhibition of attachment of Streptococcus pneumoniae and Haemophilus influenzae by human milk and receptor oligosaccharides. J. Infect. Dis 153(2):232–37 - PubMed
1. Angeloni S, Ridet JL, Kusy N, Gao H, Crevoisier F, et al. 2005. Glycoprofiling with micro-arrays of glycoconjugates and lectins. Glycobiology 15:31–41 - PubMed
1. Asakuma S, Urashima T, Akahori M, Obayashi H, Nakamura T, et al. 2007. Variation of major neutral oligosaccharides levels in human colostrum. Eur. J. Clin. Nutr 62:488–94 - PubMed

The influence of milk oligosaccharides on microbiota of infants: opportunities for formulas - PubMed (original) (raw)