Proteostasis of tau. Tau overexpression results in its secretion via membrane vesicles - PubMed (original) (raw)
. 2012 Jan 2;586(1):47-54.
doi: 10.1016/j.febslet.2011.11.022. Epub 2011 Nov 28.
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- PMID: 22138183
- DOI: 10.1016/j.febslet.2011.11.022
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Proteostasis of tau. Tau overexpression results in its secretion via membrane vesicles
Diana Simón et al. FEBS Lett. 2012.
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Abstract
Increasing amounts of tau protein were expressed in non-neuronal cells. When intracellular amounts reached a threshold level, tau protein was released to the extracellular culture medium in association with membrane vesicles. Hence, we propose that tau might be secreted through membrane vesicles as a cellular mechanism to eliminate the excess of tau protein, thereby avoiding its toxicity.
Copyright © 2011 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
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