Puzzling over schizophrenia: schizophrenia as a pathway disease - PubMed (original) (raw)

Puzzling over schizophrenia: schizophrenia as a pathway disease

Patrick F Sullivan. Nat Med. 2012.

No abstract available

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Figures

Figure

Schematic of schizophrenia as a pathway disease. Genetic variants at many loci encode the components of a pathway or pathways. Many risk loci can be affected, resulting in a disease pathway greatly modified owing to polygenetic variation. When a few risk loci are affected, there may be limited impact on the disease pathway. This pathway itself—in conjunction with environmental risk factors or other factors—mediates risk of schizophrenia.

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