Persistence of CD30 expression in Hodgkin lymphoma following brentuximab vedotin (SGN-35) treatment failure - PubMed (original) (raw)

Case Reports

Persistence of CD30 expression in Hodgkin lymphoma following brentuximab vedotin (SGN-35) treatment failure

Nitya Nathwani et al. Leuk Lymphoma. 2012 Oct.

No abstract available

PubMed Disclaimer

Figures

Figure 1

Figure 1

Immunohistochemical staining showed that in Patients 1 (3 top panels) and Patient 2 (2 bottom panels), the large atypcial cells were CD30-positive (1 left panel, and 2 middle panels) and CD20-negative (2 right panels). For patient 1, we have both pre-treatment and post-treatment samples with immunohistochemical staining. For CD30 immunostainining, we used the monoclonal mouse anti-human CD30, clone Ber-H2, code No M 0751 and visualized with the DAKO Envision/HRP kit, (Dakocytomation). For CD20 immunostaining, we used anti -Human CD20, clone L26 code no M 0755 and visualized with DAKO Envision/HRP kits (Dakocytomation).

References

    1. Johnson PW, Radford JA, Cullen MH, et al. Comparison of ABVD and alternating or hybrid multidrug regimens for the treatment of advanced Hodgkin’s lymphoma: results of the United Kingdom Lymphoma Group LY09 Trial (ISRCTN97144519) J Clin Oncol. 2005;23:9208–18. - PubMed
    1. Moskowitz CH, Nimer SD, Zelenetz AD, et al. A 2-step comprehensive high-dose chemoradiotherapy second-line program for relapsed and refractory Hodgkin disease: analysis by intent to treat and development of a prognostic model. Blood. 2001;97:616–23. - PubMed
    1. Schmitz N, Pfistner B, Sextro M, et al. Aggressive conventional chemotherapy compared with high-dose chemotherapy with autologous haemopoietic stem-cell transplantation for relapsed chemosensitive Hodgkin’s disease: a randomised trial. Lancet. 2002;359:2065–71. - PubMed
    1. Yuen AR, Rosenberg SA, Hoppe RT, Halpern JD, Horning SJ. Comparison between conventional salvage therapy and high-dose therapy with autografting for recurrent or refractory Hodgkin’s disease. Blood. 1997;89:814–22. - PubMed
    1. Sureda A, Robinson S, Canals C, et al. Reduced-intensity conditioning compared with conventional allogeneic stem-cell transplantation in relapsed or refractory Hodgkin’s lymphoma: an analysis from the Lymphoma Working Party of the European Group for Blood and Marrow Transplantation. J Clin Oncol. 2008;26:455–62. - PubMed

Publication types

MeSH terms

Substances

LinkOut - more resources