Nutritional B vitamin deficiency disrupts lipid metabolism causing accumulation of proatherogenic lipoproteins in the aorta adventitia of ApoE null mice - PubMed (original) (raw)
. 2012 Jul;56(7):1122-30.
doi: 10.1002/mnfr.201100694. Epub 2012 May 18.
Affiliations
- PMID: 22610982
- DOI: 10.1002/mnfr.201100694
Nutritional B vitamin deficiency disrupts lipid metabolism causing accumulation of proatherogenic lipoproteins in the aorta adventitia of ApoE null mice
Christopher J McNeil et al. Mol Nutr Food Res. 2012 Jul.
Abstract
Scope: Cardiovascular disease is the major cause of death in the world. Low dietary folate, elevated homocysteine, and high circulating cholesterol are risk factors.
Methods and results: We investigated whether folate and/or B vitamin deficiency would change lipoprotein and fatty acid metabolism and lipid accumulation in the aorta adventitia of ApoE null mice. Mice (n = 10 per group) were fed a control (C; 4%) or high saturated fat (HF; 21%), and high cholesterol (0.15%) diet for 16 weeks. Folate (F-) or folate, B6 and B12 deficiency (F-B-) were imposed on these diets. Feeding a HF diet increased plasma and liver total cholesterol and HDL cholesterol (two- to threefold; p < 0.05). Total cholesterol increased (twofold; p < 0.05) in aorta adventitial lipid in response to HF. Feeding a diet depleted of folate and B vitamins (F-B-) significantly increased cholesterol accumulation in both liver and aorta adventitial lipid (approximately 50-70%; p < 0.05). Moreover, the proportions of fatty acids in hepatic and adventitial lipid was significantly changed by B vitamin depletion, measured as an increase in saturated fatty acids (approximately 15%) and a decrease (approximately 11%) in monounsaturated fatty acids (p < 0.05).
Conclusion: B vitamin deficiency perturbs lipid metabolism in ApoE null mice, causing accumulation of proatherogenic cholesterol and fatty acids in the aorta adventitia.
© 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
Similar articles
- The comprehensive effects of hyperlipidemia and hyperhomocysteinemia on pathogenesis of atherosclerosis and DNA hypomethylation in ApoE-/- mice.
Jiang Y, Zhang H, Sun T, Wang J, Sun W, Gong H, Yang B, Shi Y, Wei J. Jiang Y, et al. Acta Biochim Biophys Sin (Shanghai). 2012 Oct;44(10):866-75. doi: 10.1093/abbs/gms075. Acta Biochim Biophys Sin (Shanghai). 2012. PMID: 23017835 - Diet and atherosclerosis in apolipoprotein E-deficient mice.
Imaizumi K. Imaizumi K. Biosci Biotechnol Biochem. 2011;75(6):1023-35. doi: 10.1271/bbb.110059. Epub 2011 Jun 13. Biosci Biotechnol Biochem. 2011. PMID: 21670535 Review. - Conjugated linoleic acid isomers have no effect on atherosclerosis and adverse effects on lipoprotein and liver lipid metabolism in apoE-/- mice fed a high-cholesterol diet.
Cooper MH, Miller JR, Mitchell PL, Currie DL, McLeod RS. Cooper MH, et al. Atherosclerosis. 2008 Oct;200(2):294-302. doi: 10.1016/j.atherosclerosis.2007.12.040. Epub 2008 Feb 15. Atherosclerosis. 2008. PMID: 18280484 - Urotensin II receptor knockout mice on an ApoE knockout background fed a high-fat diet exhibit an enhanced hyperlipidemic and atherosclerotic phenotype.
Bousette N, D'Orleans-Juste P, Kiss RS, You Z, Genest J, Al-Ramli W, Qureshi ST, Gramolini A, Behm D, Ohlstein EH, Harrison SM, Douglas SA, Giaid A. Bousette N, et al. Circ Res. 2009 Sep 25;105(7):686-95, 19 p following 695. doi: 10.1161/CIRCRESAHA.107.168799. Epub 2009 Aug 20. Circ Res. 2009. PMID: 19696412 - The role of dietary oxidized cholesterol and oxidized fatty acids in the development of atherosclerosis.
Staprans I, Pan XM, Rapp JH, Feingold KR. Staprans I, et al. Mol Nutr Food Res. 2005 Nov;49(11):1075-82. doi: 10.1002/mnfr.200500063. Mol Nutr Food Res. 2005. PMID: 16270280 Review.
Cited by
- MLGL-MP: a Multi-Label Graph Learning framework enhanced by pathway interdependence for Metabolic Pathway prediction.
Du BX, Zhao PC, Zhu B, Yiu SM, Nyamabo AK, Yu H, Shi JY. Du BX, et al. Bioinformatics. 2022 Jun 24;38(Suppl 1):i325-i332. doi: 10.1093/bioinformatics/btac222. Bioinformatics. 2022. PMID: 35758801 Free PMC article. - Vitamin B6 deficiency in new born rats affects hepatic cardiolipin composition and oxidative phosphorylation.
Wolke C, Gürtler S, Peter D, Weingärtner J, Domanska G, Lendeckel U, Schild L. Wolke C, et al. Exp Biol Med (Maywood). 2019 Dec;244(18):1619-1628. doi: 10.1177/1535370219889880. Epub 2019 Nov 21. Exp Biol Med (Maywood). 2019. PMID: 31752529 Free PMC article. - Stable Isotope Dilution Assays for Clinical Analyses of Folates and Other One-Carbon Metabolites: Application to Folate-Deficiency Studies.
Kopp M, Morisset R, Koehler P, Rychlik M. Kopp M, et al. PLoS One. 2016 Jun 8;11(6):e0156610. doi: 10.1371/journal.pone.0156610. eCollection 2016. PLoS One. 2016. PMID: 27276031 Free PMC article. - Nutritional B vitamin deficiency alters the expression of key proteins associated with vascular smooth muscle cell proliferation and migration in the aorta of atherosclerotic apolipoprotein E null mice.
Duthie SJ, Beattie JH, Gordon MJ, Pirie LP, Nicol F, Reid MD, Duncan GJ, Cantlay L, Horgan G, McNeil CJ. Duthie SJ, et al. Genes Nutr. 2015 Jan;10(1):446. doi: 10.1007/s12263-014-0446-y. Epub 2014 Dec 2. Genes Nutr. 2015. PMID: 25446494 Free PMC article. - High-density lipoprotein: a novel target for antirestenosis therapy.
Yin K, Agrawal DK. Yin K, et al. Clin Transl Sci. 2014 Dec;7(6):500-11. doi: 10.1111/cts.12186. Epub 2014 Jul 15. Clin Transl Sci. 2014. PMID: 25043950 Free PMC article. Review.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Medical
Research Materials
Miscellaneous