Priming of natural killer cells by nonmucosal mononuclear phagocytes requires instructive signals from commensal microbiota - PubMed (original) (raw)

. 2012 Jul 27;37(1):171-86.

doi: 10.1016/j.immuni.2012.05.020. Epub 2012 Jun 28.

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• PMID: 22749822
• DOI: 10.1016/j.immuni.2012.05.020

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Priming of natural killer cells by nonmucosal mononuclear phagocytes requires instructive signals from commensal microbiota

Stephanie C Ganal et al. Immunity. 2012.

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Abstract

Mononuclear phagocytes are an important component of an innate immune system perceived as a system ready to react upon encounter of pathogens. Here, we show that in response to microbial stimulation, mononuclear phagocytes residing in nonmucosal lymphoid organs of germ-free mice failed to induce expression of a set of inflammatory response genes, including those encoding the various type I interferons (IFN-I). Consequently, NK cell priming and antiviral immunity were severely compromised. Whereas pattern recognition receptor signaling and nuclear translocation of the transcription factors NF-κB and IRF3 were normal in mononuclear phagocytes of germ-free mice, binding to their respective cytokine promoters was impaired, which correlated with the absence of activating histone marks. Our data reveal a previously unrecognized role for postnatally colonizing microbiota in the introduction of chromatin level changes in the mononuclear phagocyte system, thereby poising expression of central inflammatory genes to initiate a powerful systemic immune response during viral infection.

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Comment in

• Maintaining poise: commensal microbiota calibrate interferon responses.
  McAleer JP, Kolls JK. McAleer JP, et al. Immunity. 2012 Jul 27;37(1):10-2. doi: 10.1016/j.immuni.2012.07.001. Immunity. 2012. PMID: 22840839

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