Local isotropic phase symmetry measure for detection of beta cells and lymphocytes - PubMed (original) (raw)
Local isotropic phase symmetry measure for detection of beta cells and lymphocytes
Manohar Kuse et al. J Pathol Inform. 2011.
Abstract
Diabetes can be associated with a reduction in functional β cell mass, which must be restored if the disease is to be cured or progress is to be arrested. To study the cell count, it is also necessary to determine the number of nuclei within the insulin stained area. It can take a single experimentalist several months to complete a single study of this kind, results of which may still be quite subjective. In this paper, we propose a framework based on a novel measure of local symmetry for detection of cells. The local isotropic phase symmetry measure (LIPSyM) is designed to give high values at or near the cell centers. We demonstrate the effectiveness of our algorithm for detection of two types of specific cells in histology images, cells in mouse pancreatic sections and lymphocytes in human breast tissue. Experimental results for these two problems show that our algorithm performs better than human experts for the former problem, and outperforms the best reported results for the latter.
Keywords: Beta cell mass assessment; cell nuclei detection; local isotropic symmetry; lymphocyte detection.
Figures
Figure 1
A schematic diagram of the proposed algorithm for detection of β cells
Figure 2
(a) Original color image; (b) H-stain; (c) Normalized median phase energy; (d) Peaks overlayed; (e) Result after clustering; (f) Final output of the algorithm
Figure 3
Isotropic (red) vs. anisotropic (green) peaks of local phase symmetry
Similar articles
- Folic acid supplementation and malaria susceptibility and severity among people taking antifolate antimalarial drugs in endemic areas.
Crider K, Williams J, Qi YP, Gutman J, Yeung L, Mai C, Finkelstain J, Mehta S, Pons-Duran C, Menéndez C, Moraleda C, Rogers L, Daniels K, Green P. Crider K, et al. Cochrane Database Syst Rev. 2022 Feb 1;2(2022):CD014217. doi: 10.1002/14651858.CD014217. Cochrane Database Syst Rev. 2022. PMID: 36321557 Free PMC article. - Localisation of luminal epithelium edge in digital histopathology images of IHC stained slides of endometrial biopsies.
Li G, Sanchez V, Patel G, Quenby S, Rajpoot N. Li G, et al. Comput Med Imaging Graph. 2015 Jun;42:56-64. doi: 10.1016/j.compmedimag.2014.11.007. Epub 2014 Nov 18. Comput Med Imaging Graph. 2015. PMID: 25529641 - Digital Breast Tomosynthesis with Hologic 3D Mammography Selenia Dimensions System for Use in Breast Cancer Screening: A Single Technology Assessment [Internet].
Movik E, Dalsbø TK, Fagelund BC, Friberg EG, Håheim LL, Skår Å. Movik E, et al. Oslo, Norway: Knowledge Centre for the Health Services at The Norwegian Institute of Public Health (NIPH); 2017 Sep 4. Report from the Norwegian Institute of Public Health No. 2017-08. Oslo, Norway: Knowledge Centre for the Health Services at The Norwegian Institute of Public Health (NIPH); 2017 Sep 4. Report from the Norwegian Institute of Public Health No. 2017-08. PMID: 29553669 Free Books & Documents. Review. - FreeStyle Libre Flash Glucose Self-Monitoring System: A Single-Technology Assessment [Internet].
Bidonde J, Fagerlund BC, Frønsdal KB, Lund UH, Robberstad B. Bidonde J, et al. Oslo, Norway: Knowledge Centre for the Health Services at The Norwegian Institute of Public Health (NIPH); 2017 Aug 21. Report from the Norwegian Institute of Public Health No. 2017-07. Oslo, Norway: Knowledge Centre for the Health Services at The Norwegian Institute of Public Health (NIPH); 2017 Aug 21. Report from the Norwegian Institute of Public Health No. 2017-07. PMID: 29553668 Free Books & Documents. Review.
Cited by
- NDG-CAM: Nuclei Detection in Histopathology Images with Semantic Segmentation Networks and Grad-CAM.
Altini N, Brunetti A, Puro E, Taccogna MG, Saponaro C, Zito FA, De Summa S, Bevilacqua V. Altini N, et al. Bioengineering (Basel). 2022 Sep 15;9(9):475. doi: 10.3390/bioengineering9090475. Bioengineering (Basel). 2022. PMID: 36135021 Free PMC article. - Segmentation of Organs and Tumor within Brain Magnetic Resonance Images Using K-Nearest Neighbor Classification.
Yoganathan SA, Zhang R. Yoganathan SA, et al. J Med Phys. 2022 Jan-Mar;47(1):40-49. doi: 10.4103/jmp.jmp_87_21. Epub 2022 Mar 31. J Med Phys. 2022. PMID: 35548028 Free PMC article. - Microscopic nuclei classification, segmentation, and detection with improved deep convolutional neural networks (DCNN).
Alom Z, Asari VK, Parwani A, Taha TM. Alom Z, et al. Diagn Pathol. 2022 Apr 19;17(1):38. doi: 10.1186/s13000-022-01189-5. Diagn Pathol. 2022. PMID: 35436941 Free PMC article. - Local Integral Regression Network for Cell Nuclei Detection.
Zhou X, Gu M, Cheng Z. Zhou X, et al. Entropy (Basel). 2021 Oct 14;23(10):1336. doi: 10.3390/e23101336. Entropy (Basel). 2021. PMID: 34682060 Free PMC article. - System for quantitative evaluation of DAB&H-stained breast cancer biopsy digital images (CHISEL).
Roszkowiak L, Korzynska A, Siemion K, Zak J, Pijanowska D, Bosch R, Lejeune M, Lopez C. Roszkowiak L, et al. Sci Rep. 2021 Apr 29;11(1):9291. doi: 10.1038/s41598-021-88611-y. Sci Rep. 2021. PMID: 33927266 Free PMC article.
References
- Slack JM. Developmental biology of the pancreas. Development. 1995;121:1569–80. - PubMed
- Butler AE, Janson J, Soeller WC, Butler PC. Increased β-cell apoptosis prevents adaptive increase in β-cell mass in mouse model of type 2 diabetes. Diabetes. 2003;52:2304–14. - PubMed
- Lavine JA, Attie AD. Gastrointestinal hormones and the regulation of β-cell mass. Ann N Y Acad Sci. 2010 Nov;1212:41–58. - PubMed
- Rahier J, Guiot Y, Goebbels RM, Sempoux C, Henquin JC. Pancreatic β-cell mass in European subjects with type 2 diabetes. Diabetes Obes Metab. 2008;10(Suppl 4):32–42. - PubMed
- Xiong G, Zhou X, Ji L. Automated segmentation of drosophila RNAi fluorescence cellular images using deformable models. Circuits and Systems I: Regular Papers, IEEE Transactions on. 2006;53:2415-24–2006.