Thymus mastichina: chemical constituents and their anti-cancer activity - PubMed (original) (raw)
Affiliations
- PMID: 23285814
Thymus mastichina: chemical constituents and their anti-cancer activity
Joana Gordo et al. Nat Prod Commun. 2012 Nov.
Abstract
The cytotoxicity-guided study of the dichloromethane and ethanol extracts of Thymus mastichina L. using the HCT colon cancer cell line allowed the identification of nine compounds, sakuranetin (1), sterubin (2), oleanolic acid (3), ursolic acid (4), lutein (5), beta-sitosterol (6), rosmarinic acid (7), 6-hydroxyluteolin-7-O-beta-glucopyranoside (8), and 6-hydroxyapigenin-7-O-beta-glucopyranoside (9). All compounds were tested for their cytotoxicity against the HCT colon cancer cell line. Compound 4 showed cytotoxicity with GI50 value of 6.8 microg/mL. A fraction composed of a mixture (1:1) of triterpenoid acids 3 and 4 displayed improved cytotoxicity with a GI50 of 2.8 microg/mL suggesting a synergistic behavior. This is the first report on the chemical constituents of Thymus mastichina L. based on structural assignments by spectroscopic analysis. The presence of these constituents identified by colon cancer cytotoxicity-guided activity indicates that extracts of T. mastichina L. may have a protective effect against colon cancers.
Similar articles
- Phytochemical investigations and antiproliferative secondary metabolites from Thymus alternans growing in Slovakia.
Dall'Acqua S, Peron G, Ferrari S, Gandin V, Bramucci M, Quassinti L, Mártonfi P, Maggi F. Dall'Acqua S, et al. Pharm Biol. 2017 Dec;55(1):1162-1170. doi: 10.1080/13880209.2017.1291689. Pharm Biol. 2017. PMID: 28222613 Free PMC article. - Cytotoxic activity of Brazilian Cerrado plants used in traditional medicine against cancer cell lines.
de Mesquita ML, de Paula JE, Pessoa C, de Moraes MO, Costa-Lotufo LV, Grougnet R, Michel S, Tillequin F, Espindola LS. de Mesquita ML, et al. J Ethnopharmacol. 2009 Jun 25;123(3):439-45. doi: 10.1016/j.jep.2009.03.018. Epub 2009 Mar 26. J Ethnopharmacol. 2009. PMID: 19501276 - Sterols, triterpenes and biflavonoids of Viburnum jucundum and cytotoxic activity of ursolic acid.
Rios MY, González-Morales A, Villarreal ML. Rios MY, et al. Planta Med. 2001 Oct;67(7):683-4. doi: 10.1055/s-2001-17357. Planta Med. 2001. PMID: 11582553 - Chemical constituents of propolis from Myanmar and their preferential cytotoxicity against a human pancreatic cancer cell line.
Li F, Awale S, Zhang H, Tezuka Y, Esumi H, Kadota S. Li F, et al. J Nat Prod. 2009 Jul;72(7):1283-7. doi: 10.1021/np9002433. J Nat Prod. 2009. PMID: 19572611 - Cytotoxic triterpene saponins from the leaves of Aralia elata.
Zhang Y, Ma Z, Hu C, Wang L, Li L, Song S. Zhang Y, et al. Fitoterapia. 2012 Jun;83(4):806-11. doi: 10.1016/j.fitote.2012.03.015. Epub 2012 Mar 20. Fitoterapia. 2012. PMID: 22465503
Cited by
- Antifungal and anti-inflammatory potential of the endangered aromatic plant Thymus albicans.
Roxo M, Zuzarte M, Gonçalves MJ, Alves-Silva JM, Cavaleiro C, Cruz MT, Salgueiro L. Roxo M, et al. Sci Rep. 2020 Nov 2;10(1):18859. doi: 10.1038/s41598-020-75244-w. Sci Rep. 2020. PMID: 33139758 Free PMC article. - Anti-Warburg effect of rosmarinic acid via miR-155 in gastric cancer cells.
Han S, Yang S, Cai Z, Pan D, Li Z, Huang Z, Zhang P, Zhu H, Lei L, Wang W. Han S, et al. Drug Des Devel Ther. 2015 May 19;9:2695-703. doi: 10.2147/DDDT.S82342. eCollection 2015. Drug Des Devel Ther. 2015. PMID: 26056431 Free PMC article. - Essential Oils from Côa Valley Lamiaceae Species: Cytotoxicity and Antiproliferative Effect on Glioblastoma Cells.
Marques MP, Neves BG, Varela C, Zuzarte M, Gonçalves AC, Dias MI, Amaral JS, Barros L, Magalhães M, Cabral C. Marques MP, et al. Pharmaceutics. 2023 Jan 19;15(2):341. doi: 10.3390/pharmaceutics15020341. Pharmaceutics. 2023. PMID: 36839664 Free PMC article. - Chromosome-level genome of Thymus mandschuricus reveals molecular mechanism of aroma compounds biosynthesis.
Jia L, Xu N, Xia B, Gao W, Meng Q, Li Q, Sun Y, Xu S, He M, Gu H. Jia L, et al. Front Plant Sci. 2024 Mar 13;15:1368869. doi: 10.3389/fpls.2024.1368869. eCollection 2024. Front Plant Sci. 2024. PMID: 38545395 Free PMC article. - Metabolomics Reveals Glycerophospholipids, Peptides, and Flavonoids Contributing to Breast Meat Flavor and Benefit Properties of Beijing-You Chicken.
Zhang J, Chen X, Cao J, Geng A, Chu Q, Yan Z, Zhang Y, Liu H. Zhang J, et al. Foods. 2024 Aug 15;13(16):2549. doi: 10.3390/foods13162549. Foods. 2024. PMID: 39200476 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Medical