IGFBP-2 is a negative predictor of cold-induced brown fat and bone mineral density in young non-obese women - PubMed (original) (raw)

IGFBP-2 is a negative predictor of cold-induced brown fat and bone mineral density in young non-obese women

Miriam A Bredella et al. Bone. 2013 Apr.

Abstract

Recent studies have shown a positive correlation between brown adipose tissue (BAT) and bone mineral density (BMD). However, mechanisms underlying this relationship are unknown. Insulin-like growth factor 1 (IGF-1) is an important regulator of stem cell differentiation promoting bone formation. IGF binding protein 2 (IGFBP-2) binds IGF-1 in the circulation and has been reported to inhibit bone formation in humans. IGF-1 is also a crucial regulator of brown adipocyte differentiation. We hypothesized that IGFBP-2 is a negative and IGF-1 a positive regulator of BAT-mediated osteoblastogenesis. We therefore investigated a cohort of 15 women (mean age 27.7±5.7years): 5 with anorexia nervosa (AN) in whom IGF-1 levels were low due to starvation, 5 recovered AN (AN-R), and 5 women of normal weight. All subjects underwent assessment of cold-activated BAT by PET/CT, BMD of the spine, hip, femoral neck, and total body by DXA, thigh muscle area by MRI, IGF-1 and IGFBP-2. There was a positive correlation between BAT and BMD and an inverse association between IGFBP-2 and both BAT and BMD. There was no association between IGF-1 and BAT. We show for the first time that IGFBP-2 is a negative predictor of cold-induced BAT and BMD in young non-obese women, suggesting that IGFBP-2 may serve as a regulator of BAT-mediated osteoblastogenesis.

Copyright © 2012 Elsevier Inc. All rights reserved.

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Conflict of interest statement

Disclosures: The authors have no conflict of interest to declare.

Figures

Figure 1

Figure 1

Regression analysis of brown adipose tissue (BAT) on IGFBP-2. There was an inverse association between BAT and IGFBP-2 in subjects with detectable BAT. Grey diamonds: subjects with BAT, black squares: subjects without BAT. Shaded area represents undetectable range.

Figure 2

Figure 2

Regression analysis of hip bone mineral density (BMD) on IGFBP-2. There was an inverse association between hip BMD and IGFBP-2.

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