Antioxidant action and therapeutic efficacy of Allium sativum L - PubMed (original) (raw)

Review

Antioxidant action and therapeutic efficacy of Allium sativum L

Anna Capasso. Molecules. 2013.

Abstract

Allium sativum (L.) is rich in antioxidants which help destroy free radicals particles that can damage cell membranes and DNA, and may contribute to the aging process as well as the development of a number of conditions, including heart disease and cancer. Antioxidants neutralize free radicals and may reduce or even help prevent some of the damage they cause over time. The antioxidant activity of fresh Allium sativum L. (garlic) is well known and is mainly due to unstable and irritating organosulphur compounds. Fresh garlic extracted over a prolonged period (up to 20 months) produces odourless aged garlic extract (AGE) containing stable and water soluble organosulphur compounds that prevent oxidative damage by scavenging free radicals. The aim of this review was to understand the mechanism of antioxidant action and therapeutic efficacy of garlic.

PubMed Disclaimer

Figures

Figure 1

ROS origin and pathway.

Figure 2

Proposed mechanism by diallyl trisulfide against carcinogenesis.

Similar articles

• In vitro antioxidant activity of aged extracts of some Italian Allium species.
  Nencini C, Menchiari A, Franchi GG, Micheli L. Nencini C, et al. Plant Foods Hum Nutr. 2011 Mar;66(1):11-6. doi: 10.1007/s11130-010-0204-2. Plant Foods Hum Nutr. 2011. PMID: 21290188
• Antioxidant health effects of aged garlic extract.
  Borek C. Borek C. J Nutr. 2001 Mar;131(3s):1010S-5S. doi: 10.1093/jn/131.3.1010S. J Nutr. 2001. PMID: 11238807 Review.
• Comparative studies of bioactive organosulphur compounds and antioxidant activities in garlic (Allium sativum L.), elephant garlic (Allium ampeloprasum L.) and onion (Allium cepa L.).
  Kim S, Kim DB, Jin W, Park J, Yoon W, Lee Y, Kim S, Lee S, Kim S, Lee OH, Shin D, Yoo M. Kim S, et al. Nat Prod Res. 2018 May;32(10):1193-1197. doi: 10.1080/14786419.2017.1323211. Epub 2017 May 5. Nat Prod Res. 2018. PMID: 28475377
• Garlic: nature's protection against physiological threats.
  Butt MS, Sultan MT, Butt MS, Iqbal J. Butt MS, et al. Crit Rev Food Sci Nutr. 2009 Jun;49(6):538-51. doi: 10.1080/10408390802145344. Crit Rev Food Sci Nutr. 2009. PMID: 19484634 Review.
• Hepatoprotective and antioxidant effects of single clove garlic against CCl4-induced hepatic damage in rabbits.
  Naji KM, Al-Shaibani ES, Alhadi FA, Al-Soudi SA, D'souza MR. Naji KM, et al. BMC Complement Altern Med. 2017 Aug 17;17(1):411. doi: 10.1186/s12906-017-1916-8. BMC Complement Altern Med. 2017. PMID: 28818066 Free PMC article.

Cited by

• Kimchi and Other Widely Consumed Traditional Fermented Foods of Korea: A Review.
  Patra JK, Das G, Paramithiotis S, Shin HS. Patra JK, et al. Front Microbiol. 2016 Sep 28;7:1493. doi: 10.3389/fmicb.2016.01493. eCollection 2016. Front Microbiol. 2016. PMID: 27733844 Free PMC article. Review.
• Protective effect of aged garlic extracts against hepatotoxicity induced by ethephon in Wistar albino rat.
  Al-Brakati A. Al-Brakati A. Environ Sci Pollut Res Int. 2020 Feb;27(6):6139-6147. doi: 10.1007/s11356-019-07148-w. Epub 2019 Dec 21. Environ Sci Pollut Res Int. 2020. PMID: 31865585
• A possible mechanism of inhibition of U87MG and SH-SY5Y cancer cell proliferation by diallyl trisulfide and other aspects of its activity.
  Jurkowska H, Wróbel M, Kaczor-Kamińska M, Jasek-Gajda E. Jurkowska H, et al. Amino Acids. 2017 Nov;49(11):1855-1866. doi: 10.1007/s00726-017-2484-4. Epub 2017 Aug 29. Amino Acids. 2017. PMID: 28852876 Free PMC article.
• Garlic Consumption and All-Cause Mortality among Chinese Oldest-Old Individuals: A Population-Based Cohort Study.
  Shi X, Lv Y, Mao C, Yuan J, Yin Z, Gao X, Zhang Z. Shi X, et al. Nutrients. 2019 Jun 30;11(7):1504. doi: 10.3390/nu11071504. Nutrients. 2019. PMID: 31262080 Free PMC article.
• Garlic: a review of potential therapeutic effects.
  Bayan L, Koulivand PH, Gorji A. Bayan L, et al. Avicenna J Phytomed. 2014 Jan;4(1):1-14. Avicenna J Phytomed. 2014. PMID: 25050296 Free PMC article. Review.

References

1. 1. Finkel T., Holbrook N.J. Oxidants, oxidative stress and the biology of ageing. Nature. 2000;408:239–247. doi: 10.1038/35041687. - DOI - PubMed
2. 1. Ferrara N., Gorbi G., Scarpa D., Rengo G., Longobardi G. Teorie dll’invecchiamento. The aging theories. G Gerontol. 2005;53:57–74.
3. 1. Bergamini C.M., Gambetti S., Dondi A., Cervellati C. Oxygen, reactive oxygen species and tissue damage. Curr. Pharm. Des. 2004;10:1611–1626. - PubMed
4. 1. Leonard S.S., Cutler D., Ding M., Vallyathan V., Castranova V., Shi X. Antioxidant properties of fruit and vegetable juices: More to the story than ascorbic acid. Ann. Clin. Lab. Sci. 2002;32:193–200. - PubMed
5. 1. Augusti K.T. Therapeutic values of onion (Allium cepa L.) and garlic (Allium sativum L.) Indian J. Exp. Biol. 1996;34:634–640. - PubMed

Publication types

MeSH terms

Substances

LinkOut - more resources

• Full Text Sources

  • Europe PubMed Central
  • MDPI
  • PubMed Central

• Other Literature Sources

  • scite Smart Citations

• Medical

  • MedlinePlus Health Information