LADA: time for a new definition - PubMed (original) (raw)

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LADA: time for a new definition

Maria J Redondo. Diabetes. 2013 Feb.

No abstract available

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Figures

FIG. 1.

Model of progression to diabetes determined by insulin secretion and insulin resistance. Clinical diabetes manifests when anti-islet autoimmunity (in T1D) or nonautoimmune β-cell dysfunction (in T2D) decrease insulin secretory capacity below a threshold determined by insulin resistance, which can vary from low (in T1D) to high (in T2D). Although not illustrated in this figure, variation in the rate of insulin secretion decrease also determines time to progression to diabetes. In LADA, as opposed to T1D and T2D, three mechanisms, namely, anti-islet autoimmunity, nonautoimmune β-cell dysfunction, and elevated insulin resistance, likely contribute to disease.

Comment on

• Frequency, immunogenetics, and clinical characteristics of latent autoimmune diabetes in China (LADA China study): a nationwide, multicenter, clinic-based cross-sectional study.
  Zhou Z, Xiang Y, Ji L, Jia W, Ning G, Huang G, Yang L, Lin J, Liu Z, Hagopian WA, Leslie RD; LADA China Study Group. Zhou Z, et al. Diabetes. 2013 Feb;62(2):543-50. doi: 10.2337/db12-0207. Epub 2012 Oct 18. Diabetes. 2013. PMID: 23086039 Free PMC article.

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