Latent autoimmune diabetes in adults is perched between type 1 and type 2: evidence from adults in one region of Spain - PubMed (original) (raw)
Comparative Study
doi: 10.1002/dmrr.2411.
Collaborators, Affiliations
- PMID: 23483713
- DOI: 10.1002/dmrr.2411
Comparative Study
Latent autoimmune diabetes in adults is perched between type 1 and type 2: evidence from adults in one region of Spain
Angels Mollo et al. Diabetes Metab Res Rev. 2013 Sep.
Erratum in
- Diabetes Metab Res Rev. 2013 Nov;29(8):693. Action LADA 8 [added]; multiple investigator names added
- Addendum.
[No authors listed] [No authors listed] Diabetes Metab Res Rev. 2018 Jul;34(5):e3017. doi: 10.1002/dmrr.3017. Diabetes Metab Res Rev. 2018. PMID: 29972288 No abstract available.
Abstract
Background: The aim of this study was to characterize the clinical characteristics and insulin secretion in adults with latent autoimmune diabetes in adults (LADA). We also compared these characteristics in subjects with antibody-negative type 2 diabetes (T2DM) or adult-onset type 1 diabetes (T1DM) to subjects with LADA.
Methods: In this cross-sectional study, 82 patients with LADA, 78 with T1DM and 485 with T2DM were studied. Clinical and metabolic data, in particular those that related to metabolic syndrome, fasting C-peptide and islet-cell autoantibodies [glutamic acid decarboxylase (GADAb) and IA2 (IA2Ab)] were measured.
Results: The frequency of metabolic syndrome in patients with LADA (37.3%) was higher than in those with T1DM (15.5%; p = 0.005) and lower than in patients with T2DM (67.2%; p < 0.001). During the first 36 months of the disease, the C-peptide concentration in LADA patients was higher than in subjects with T1DM but was lower than in T2DM patients (p < 0.01 for comparisons). Glycemic control in LADA patients (HbA1c 8.1%) was worse than in patients with T2DM (HbA1c 7.6%; p =0.007). An inverse association between GADAb titers and C-peptide concentrations was found in subjects with LADA (p < 0.001). Finally, LADA patients rapidly progressed to insulin treatment.
Conclusions: As in other European populations, patients with LADA in Spain have a distinct metabolic profile compared with patients with T1DM or T2DM. LADA is also associated with higher impairment of beta-cell function and has worse glycemic control than in T2DM. Beta cell function is related to GADAb titers in patients with LADA.
Keywords: C-peptide; glutamic acid decarboxylase antibodies; latent autoimmune diabetes in adults; metabolic syndrome; type 1 diabetes mellitus; type 2 diabetes mellitus.
Copyright © 2013 John Wiley & Sons, Ltd.
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