Intracellular pathogen detection by RIG-I-like receptors - PubMed (original) (raw)

Review

Intracellular pathogen detection by RIG-I-like receptors

Evelyn Dixit et al. Adv Immunol. 2013.

Abstract

The RIG-I-like receptors (RLRs) RIG-I, MDA5, and LGP2 trigger innate immune responses against viral infections that serve to limit virus replication and to stimulate adaptive immunity. RLRs are cytosolic sensors for virus-derived RNA and thus responsible for intracellular immune surveillance against infection. RLR signaling requires the adapter protein MAVS to induce type I interferon, interferon-stimulated genes, and proinflammatory cytokines. This review focuses on the molecular and cell biological requirements for RLR signal transduction.

Copyright © 2013 Elsevier Inc. All rights reserved.

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