Correlation between serum vitamin d level and the severity of atopic dermatitis associated with food sensitization - PubMed (original) (raw)
Correlation between serum vitamin d level and the severity of atopic dermatitis associated with food sensitization
Seon Ah Lee et al. Allergy Asthma Immunol Res. 2013 Jul.
Abstract
Purpose: A growing body of literature has linked vitamin D deficiency with allergic diseases, particularly atopic dermatitis (AD). In this study, we investigated the association between serum vitamin D status and the clinical manifestation of AD. We also developed an analytical method for the simultaneous determination of 25-hydroxy vitamin D3 (25(OH)D3), using liquid chromatography (LC) coupled with tandem mass spectrometry (MS/MS).
Methods: This study included 157 patients (79 males and 78 females) with AD, aged 4 months to 56 years. We evaluated disease severity using the SCORing Atopic Dermatitis (SCORAD) index. Serum levels of 25(OH)D3 were determined by LC coupled with MS/MS. Total IgE and specific IgE levels were assayed using the immunoCAP system. ANOVA was used for statistical evaluation.
Results: We found mild, moderate, and severe AD in 30 (11.1%), 87 (55.4%), and 40 (25.5%) patients, respectively. There was no significant correlation between serum levels of 25(OH)D3 and AD severity. However, among the 36 patients with food sensitization, the mean±SD serum levels of 25(OH)D3 were significantly higher (P<0.05) in patients with mild disease (21.2±5.18 ng/mL) compared with the levels in patients with moderate (17.9±4.02 ng/mL) or severe AD (13.3±5.11 ng/mL) disease.
Conclusions: These results suggest that vitamin D deficiency is related to the severity of AD associated with food sensitization. Thus, these data suggest a role for vitamin D in a select group of AD patients.
Keywords: Atopic dermatitis; food allergy; vitamin D.
Conflict of interest statement
There are no financial or other issues that might lead to conflict of interest.
Figures
Fig. 1
Correlation between serum 25(OH)D3 levels and individual atopic dermatitis disease severity.
Fig. 2
Serum 25(OH)D3 levels according to atopic dermatitis severity associated with food sensitization. Circles indicate mean values.
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References
- Department for Environment, Food and Rural Affairs. Consumption of selected household foods (GB) 1942 to 2000 [Internet] London: HMSO; [accessed 2004 Jan 11]. Available from: www.defra.gov.uk/statistics/files/defra-stats-family-food-nfs-allfood.xls.
- Camargo CA, Jr, Clark S, Kaplan MS, Lieberman P, Wood RA. Regional differences in EpiPen prescriptions in the United States: the potential role of vitamin D. J Allergy Clin Immunol. 2007;120:131–136. - PubMed
- Ehlayel MS, Bener A, Sabbah A. Is high prevalence of vitamin D deficiency evidence for asthma and allergy risks? Eur Ann Allergy Clin Immunol. 2011;43:81–88. - PubMed
- Benson AA, Toh JA, Vernon N, Jariwala SP. The role of vitamin D in the immunopathogenesis of allergic skin diseases. Allergy. 2012;67:296–301. - PubMed
- Hanifin JM, Rajka G. Diagnostic features of atopic dermatitis. Acta Derm Venereol Suppl (Stockh) 1980;92:44–47.
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