Prenatal vitamin d supplementation and child respiratory health: a randomised controlled trial - PubMed (original) (raw)
Randomized Controlled Trial
. 2013 Jun 24;8(6):e66627.
doi: 10.1371/journal.pone.0066627. Print 2013.
Chris J Griffiths, Adrian R Martineau, Stephen Robinson, Christina Yu, Sheree Poulton, Jane C Kirkby, Janet Stocks, Richard Hooper, Seif O Shaheen, John O Warner, Robert J Boyle
Affiliations
- PMID: 23826104
- PMCID: PMC3691177
- DOI: 10.1371/journal.pone.0066627
Randomized Controlled Trial
Prenatal vitamin d supplementation and child respiratory health: a randomised controlled trial
Stephen T Goldring et al. PLoS One. 2013.
Abstract
Background: Observational studies suggest high prenatal vitamin D intake may be associated with reduced childhood wheezing. We examined the effect of prenatal vitamin D on childhood wheezing in an interventional study.
Methods: We randomised 180 pregnant women at 27 weeks gestation to either no vitamin D, 800 IU ergocalciferol daily until delivery or single oral bolus of 200,000 IU cholecalciferol, in an ethnically stratified, randomised controlled trial. Supplementation improved but did not optimise vitamin D status. Researchers blind to allocation assessed offspring at 3 years. Primary outcome was any history of wheeze assessed by validated questionnaire. Secondary outcomes included atopy, respiratory infection, impulse oscillometry and exhaled nitric oxide. Primary analyses used logistic and linear regression.
Results: We evaluated 158 of 180 (88%) offspring at age 3 years for the primary outcome. Atopy was assessed by skin test for 95 children (53%), serum IgE for 86 (48%), exhaled nitric oxide for 62 (34%) and impulse oscillometry of acceptable quality for 51 (28%). We found no difference between supplemented and control groups in risk of wheeze [no vitamin D: 14/50 (28%); any vitamin D: 26/108 (24%) (risk ratio 0.86; 95% confidence interval 0.49, 1.50; P = 0.69)]. There was no significant difference in atopy, eczema risk, lung function or exhaled nitric oxide between supplemented groups and controls.
Conclusion: Prenatal vitamin D supplementation in late pregnancy that had a modest effect on cord blood vitamin D level, was not associated with decreased wheezing in offspring at age three years.
Trial registration: Controlled-Trials.com ISRCTN68645785.
Conflict of interest statement
Competing Interests: The authors have declared that no competing interests exist.
Figures
Figure 1. Recruitment and follow up of study participants.
Figure 2. Baseline respiratory resistance at 10 Hz (R10, A), 20 Hz (R20, B), resonant frequency (Fres, C) and area under the reactance curve (AX, D) for control (n = 13), daily (n = 18), and bolus (n = 20) vitamin D groups at age three years.
Horizontal bars represent means. No significant difference between groups.
Figure 3. Bronchodilator response for respiratory resistance at 10 Hz (R10, A), 20 Hz (R20, B), resonant frequency (Fres, C) and area under the reactance curve (AX, D) for control (n = 10), daily (n = 15), and bolus (n = 14) vitamin D groups at age three years.
Horizontal bars represent means. No significant difference between groups.
Figure 4. Measures of allergic inflammation at age three years.
Ln IgE (A; n = 86), eNO (B; n = 62), and Ln eosinophil count (C; n = 90). Control versus daily and bolus vitamin D. Horizontal bars represent means. No significant difference between groups.
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References
- Devereux G, Litonjua AA, Turner SW, Craig LC, McNeill G, et al. (2007) Maternal vitamin D intake during pregnancy and early childhood wheezing. Am J Clin Nutr 85: 853–859. - PubMed
- Miyake Y, Sasaki S, Tanaka K, Hirota Y (2010) Dairy food, calcium and vitamin D intake in pregnancy, and wheeze and eczema in infants. Eur Respir J 35: 1228–1234. - PubMed
- Erkkola M, Kaila M, Nwaru BI, Kronberg-Kippila C, Ahonen S, et al. (2009) Maternal vitamin D intake during pregnancy is inversely associated with asthma and allergic rhinitis in 5-year-old children. Clin Exp Allergy 39: 875–882. - PubMed
- Millen AE, Bodnar LM (2008) Vitamin D assessment in population-based studies: a review of the issues. Am J Clin Nutr 87: 1102S–1105S. - PubMed
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