Bed rest worsens impairments in fat and glucose metabolism in older, overweight adults - PubMed (original) (raw)

Bed rest worsens impairments in fat and glucose metabolism in older, overweight adults

Robert H Coker et al. J Gerontol A Biol Sci Med Sci. 2014 Mar.

Abstract

Background: The effects of bed rest on the dysregulation of fatty acid and glucose metabolism have not been addressed in the older population.

Objective: We examined the effect of 10 days of bed rest on fatty acid kinetics and hepatic and peripheral insulin resistance in aging.

Methods: We utilized an octreotide, basal glucagon replacement, multistage insulin infusion, and the concomitant infusion of [6,6 (2)H₂]glucose to derive insulin-mediated suppression of glucose production and insulin-stimulated glucose disposal in nine older, overweight individuals (body mass index 28.1 ± 1.7 kg m(-2); 39.9% ± 1.9% fat). During the multistage insulin infusion, we also infused [1-(13)C]palmitate to examine free fatty acid rate of appearance (R(a)).

Results: Body weight, % body fat, and energy metabolism did not change with bed rest. There was a significant decrease (-2291 ± 316 cm(3)) in visceral fat, and no change in abdominal subcutaneous fat with bed rest. Insulin-mediated suppression of glucose production was modest prior to bed rest and was further reduced (>15% ± 2%) by bed rest. There was also a minor decrease in the insulin-mediated suppression of free fatty acid R(a) after bed rest and, as a consequence, a small variation in plasma free fatty acid from pre- to post-bed rest in the first stage of the multistage insulin infusion. There was also a significant bed rest-induced decline (>2.0 ± 0.6 mg kg FFM(-1) min(-1)) in insulin-stimulated glucose disposal.

Conclusions: Preexisting impairments in insulin sensitivity are worsened by bed rest and seem linked to alterations in the regulation of free fatty acid in older, overweight individuals.

Keywords: Hospitalization; Inactivity; Metabolic disease..

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Figures

Figure 1.

Figure 1.

Insulin-stimulated suppression of glucose R a under pre- and post-bed rest conditions. *Denotes a significant reduction.

Figure 2.

Figure 2.

Insulin-stimulated glucose disposal under pre- and post-bed rest conditions. *Denotes a significant reduction.

Figure 3.

Figure 3.

Total free fatty acid rate of appearance under basal, and mild and moderate hyperinsulinemia during the pre- and post-bed rest conditions of the multistage insulin infusion. *Denotes a significant increase from preintervention to postintervention.

Figure 4.

Figure 4.

Plasma free fatty acid concentrations under basal, and mild and moderate hyperinsulinemia during the pre- and post-bed rest conditions of the multistage insulin infusion. *Denotes a significant increase from preintervention to postintervention.

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