Effect of vitamin D supplementation on antibiotic use: a randomized controlled trial - PubMed (original) (raw)
Randomized Controlled Trial
doi: 10.3945/ajcn.113.063271. Epub 2013 Oct 9.
Affiliations
- PMID: 24108783
- DOI: 10.3945/ajcn.113.063271
Free article
Randomized Controlled Trial
Effect of vitamin D supplementation on antibiotic use: a randomized controlled trial
Bich Tran et al. Am J Clin Nutr. 2014 Jan.
Free article
Abstract
Background: Observational data suggested that supplementation with vitamin D could reduce risk of infection, but trial data are inconsistent.
Objective: We aimed to examine the effect of oral vitamin D supplementation on antibiotic use.
Design: We conducted a post hoc analysis of data from pilot D-Health, which is a randomized trial carried out in a general community setting between October 2010 and February 2012. A total of 644 Australian residents aged 60-84 y were randomly assigned to receive monthly doses of a placebo (n = 214) or 30,000 (n = 215) or 60,000 (n = 215) IU oral cholecalciferol for ≤12 mo. Antibiotics prescribed during the intervention period were ascertained by linkage with pharmacy records through the national health insurance scheme (Medicare Australia).
Results: People who were randomly assigned 60,000 IU cholecalciferol had nonsignificant 28% lower risk of having antibiotics prescribed at least once than did people in the placebo group (RR: 0.72; 95% CI: 0.48, 1.07). In analyses stratified by age, in subjects aged ≥70 y, there was a significant reduction in antibiotic use in the high-dose vitamin D compared with placebo groups (RR: 0.53; 95% CI: 0.32, 0.90), whereas there was no effect in participants aged <70 y (RR: 1.07; 95% CI: 0.58, 1.97) (P-interaction = 0.1).
Conclusion: Although this study was a post hoc analysis and statistically nonsignificant, this trial lends some support to the hypothesis that supplementation with 60,000 IU vitamin D/mo is associated with lower risk of infection, particularly in older adults. The trial was registered at the Australian New Zealand Clinical Trials Registry (anzctr.org.au) as ACTRN12609001063202.
Comment in
- Vitamin D supplementation and risk of infectious disease: no easy answers.
Camargo CA Jr, Manson JE. Camargo CA Jr, et al. Am J Clin Nutr. 2014 Jan;99(1):3-4. doi: 10.3945/ajcn.113.078329. Epub 2013 Nov 27. Am J Clin Nutr. 2014. PMID: 24284446 Free PMC article. No abstract available.
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