Intestinal epithelial cells: regulators of barrier function and immune homeostasis - PubMed (original) (raw)

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doi: 10.1038/nri3608.

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• PMID: 24566914
• DOI: 10.1038/nri3608

Review

Intestinal epithelial cells: regulators of barrier function and immune homeostasis

Lance W Peterson et al. Nat Rev Immunol. 2014 Mar.

Abstract

The abundance of innate and adaptive immune cells that reside together with trillions of beneficial commensal microorganisms in the mammalian gastrointestinal tract requires barrier and regulatory mechanisms that conserve host-microbial interactions and tissue homeostasis. This homeostasis depends on the diverse functions of intestinal epithelial cells (IECs), which include the physical segregation of commensal bacteria and the integration of microbial signals. Hence, IECs are crucial mediators of intestinal homeostasis that enable the establishment of an immunological environment permissive to colonization by commensal bacteria. In this Review, we provide a comprehensive overview of how IECs maintain host-commensal microbial relationships and immune cell homeostasis in the intestine.

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• Innate lymphoid cells: nutrients direct immune balance.
  Kugelberg E. Kugelberg E. Nat Rev Immunol. 2014 Mar;14(3):137. doi: 10.1038/nri3626. Epub 2014 Feb 7. Nat Rev Immunol. 2014. PMID: 24503524 No abstract available.

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