Regulation of an antioxidant blend on intestinal redox status and major microbiota in early weaned piglets - PubMed (original) (raw)

Regulation of an antioxidant blend on intestinal redox status and major microbiota in early weaned piglets

Jianxiong Xu et al. Nutrition. 2014 May.

Abstract

Objective: According to the "antioxidants network" theory, the present study was conducted to evaluate the regulation of an antioxidant blend on intestinal redox status and major microbiota of early-weaned piglets.

Methods: Piglets from 15 litters were randomly allocated by litter to the control group (suckling normally, fed the basal diet, n = 5), the weaning group (weaned at age 21 d, fed the basal diet, n = 5), and the repair group (weaned at age 21 d, fed the basal diet supplemented with an antioxidant blend, n = 5). The redox status and major microbiota in jejunum and colon tracts of 24-d-old piglets were detected, respectively.

Results: Early weaning resulted in significant decreases in jejunum and colon antioxidant capacities, Lactobacillus and Bifidobacterium counts, and significant increases in levels of jejunum malondialdehyde, colon hydroxyl radicals, jejunum and colon H2O2, and Escherichia coli counts in piglets. The observed imbalance of the intestinal redox status and microbiota was significantly restored by the antioxidant blend. Interestingly, intestinal selected antioxidative items presented a positive correlation with potential beneficial bacteria and a negative correlation with E. coli. Nevertheless, selected oxidative items and the bacteria presented an inverse relationship in piglets.

Conclusion: Supplementation of the antioxidant blend effectively restored intestinal redox status and microbiota balance in the porcine intestine in response to early weaning stress, enhancing intestinal health and function of piglets.

Keywords: Antioxidant; Intestine; Microbiota; Piglets; Redox status; Weaned.

PubMed Disclaimer

Cited by

Dietary Supplementation with Probiotic Bacillus licheniformis S6 Improves Intestinal Integrity via Modulating Intestinal Barrier Function and Microbial Diversity in Weaned Piglets.
Sun W, Chen W, Meng K, Cai L, Li G, Li X, Jiang X. Sun W, et al. Biology (Basel). 2023 Feb 2;12(2):238. doi: 10.3390/biology12020238. Biology (Basel). 2023. PMID: 36829515 Free PMC article.
Impact of Tilapia hepcidin 2-3 dietary supplementation on the gut microbiota profile and immunomodulation in the grouper (Epinephelus lanceolatus).
Ting CH, Pan CY, Chen YC, Lin YC, Chen TY, Rajanbabu V, Chen JY. Ting CH, et al. Sci Rep. 2019 Dec 13;9(1):19047. doi: 10.1038/s41598-019-55509-9. Sci Rep. 2019. PMID: 31836758 Free PMC article.
The Potential Impact of Probiotics on the Gut Microbiome of Athletes.
Wosinska L, Cotter PD, O'Sullivan O, Guinane C. Wosinska L, et al. Nutrients. 2019 Sep 21;11(10):2270. doi: 10.3390/nu11102270. Nutrients. 2019. PMID: 31546638 Free PMC article. Review.
Effects of Bacillus licheniformis on Growth Performance, Diarrhea Incidence, Antioxidant Capacity, Immune Function, and Fecal Microflora in Weaned Piglets.
Yu X, Cui Z, Qin S, Zhang R, Wu Y, Liu J, Yang C. Yu X, et al. Animals (Basel). 2022 Jun 22;12(13):1609. doi: 10.3390/ani12131609. Animals (Basel). 2022. PMID: 35804509 Free PMC article.
Diets Partially Replaced With Cassava Residue Modulate Antioxidant Capacity, Lipid Metabolism, and Gut Barrier Function of Huanjiang Mini-Pigs.
Azad MAK, Jiang H, Ni H, Liu Y, Huang P, Fang J, Kong X. Azad MAK, et al. Front Vet Sci. 2022 May 17;9:902328. doi: 10.3389/fvets.2022.902328. eCollection 2022. Front Vet Sci. 2022. PMID: 35656170 Free PMC article.

Regulation of an antioxidant blend on intestinal redox status and major microbiota in early weaned piglets - PubMed (original) (raw)