Matricryptins and matrikines: biologically active fragments of the extracellular matrix - PubMed (original) (raw)
Review
Matricryptins and matrikines: biologically active fragments of the extracellular matrix
Sylvie Ricard-Blum et al. Exp Dermatol. 2014 Jul.
Abstract
Numerous extracellular proteins and glycosaminoglycans (GAGs) undergo limited enzymatic cleavage resulting in the release of fragments exerting biological activities, which are usually different from those of the full-length molecules. In this review, we define matrikines and matricryptins, which are bioactive fragments released from the extracellular matrix proteins, proteoglycans and GAGs and report their major biological activities. These fragments regulate a number of physiopathological processes including angiogenesis, cancer, fibrosis, inflammation, neurodegenerative diseases and wound healing. The challenges to translate these fragments from molecules biologically active in vitro and in experimental models to potential drugs are discussed in the last part of the review.
Keywords: bioactive fragments; endostatin; extracellular matrix; matricryptins; matrikines.
© 2014 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.
Similar articles
- Proteases decode the extracellular matrix cryptome.
Ricard-Blum S, Vallet SD. Ricard-Blum S, et al. Biochimie. 2016 Mar;122:300-13. doi: 10.1016/j.biochi.2015.09.016. Epub 2015 Sep 14. Biochimie. 2016. PMID: 26382969 Review. - Extracellular matrix and wound healing.
Maquart FX, Monboisse JC. Maquart FX, et al. Pathol Biol (Paris). 2014 Apr;62(2):91-5. doi: 10.1016/j.patbio.2014.02.007. Epub 2014 Mar 18. Pathol Biol (Paris). 2014. PMID: 24650524 Review. - Matricryptins derived from collagens and proteoglycans.
Ricard-Blum S, Ballut L. Ricard-Blum S, et al. Front Biosci (Landmark Ed). 2011 Jan 1;16(2):674-97. doi: 10.2741/3712. Front Biosci (Landmark Ed). 2011. PMID: 21196195 Review. - Matrix glycosaminoglycans in the growth phase of fibroblasts: more of the story in wound healing.
Kosir MA, Quinn CC, Wang W, Tromp G. Kosir MA, et al. J Surg Res. 2000 Jul;92(1):45-52. doi: 10.1006/jsre.2000.5840. J Surg Res. 2000. PMID: 10864481 - Matrikines and the lungs.
Burgess JK, Weckmann M. Burgess JK, et al. Pharmacol Ther. 2012 Jun;134(3):317-37. doi: 10.1016/j.pharmthera.2012.02.002. Epub 2012 Feb 16. Pharmacol Ther. 2012. PMID: 22366287 Review.
Cited by
- Cartilage Oligomeric Matrix Protein-Derived Peptides Secreted by Cartilage Do Not Induce Responses Commonly Observed during Osteoarthritis.
Andrés Sastre E, Zaucke F, Witte-Bouma J, van Osch GJVM, Farrell E. Andrés Sastre E, et al. Cartilage. 2021 Dec;13(2_suppl):1229S-1236S. doi: 10.1177/1947603520961170. Epub 2020 Sep 29. Cartilage. 2021. PMID: 32993314 Free PMC article. - Diverse and multifunctional roles for perlecan (HSPG2) in repair of the intervertebral disc.
Melrose J, Guilak F. Melrose J, et al. JOR Spine. 2024 Jul 29;7(3):e1362. doi: 10.1002/jsp2.1362. eCollection 2024 Sep. JOR Spine. 2024. PMID: 39081381 Free PMC article. Review. - The Interplay between Extracellular Matrix Remodeling and Cancer Therapeutics.
Prakash J, Shaked Y. Prakash J, et al. Cancer Discov. 2024 Aug 2;14(8):1375-1388. doi: 10.1158/2159-8290.CD-24-0002. Cancer Discov. 2024. PMID: 39091205 Free PMC article. Review. - Proteolytic fragments of fibronectin function as matrikines driving the chemotactic affinity of prostate cancer cells to human bone marrow mesenchymal stromal cells via the α5β1 integrin.
Joshi R, Goihberg E, Ren W, Pilichowska M, Mathew P. Joshi R, et al. Cell Adh Migr. 2017 Jul 4;11(4):305-315. doi: 10.1080/19336918.2016.1212139. Epub 2016 Aug 11. Cell Adh Migr. 2017. PMID: 27715399 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources