Cell banking for pharmaceutical research - PubMed (original) (raw)

Review

. 2014 Oct;19(10):1518-29.

doi: 10.1016/j.drudis.2014.05.006. Epub 2014 May 22.

Affiliations

Review

Cell banking for pharmaceutical research

Jonathan D Wrigley et al. Drug Discov Today. 2014 Oct.

Abstract

The provision of high-quality eukaryotic cells through robust cell banking processes is essential for the progression of drug discovery projects throughout the pharmaceutical research process. Numerous models exist to meet this aim, and this review describes many of the underlying principles, challenges and opportunities as well as detailing how these have been addressed within AstraZeneca. Crucial aspects discussed include cell line acquisition, cell bank generation, cryopreservation, storage, tracking and distribution. Because quality assurance underpins much of the process, quality control (QC) testing including mycoplasma screening and cell line authentication are also discussed in detail. Furthermore, because many of the underlying principles of cell banking are applicable in non-pharmaceutical settings, it is hoped that this review will prove a useful resource across the wider scientific community.

Copyright © 2014 Elsevier Ltd. All rights reserved.

PubMed Disclaimer

Similar articles

Cited by

Publication types

MeSH terms

LinkOut - more resources