Maternal obesity, inflammation, and developmental programming - PubMed (original) (raw)

Review

Maternal obesity, inflammation, and developmental programming

Stephanie A Segovia et al. Biomed Res Int. 2014.

Abstract

The prevalence of obesity, especially in women of child-bearing age, is a global health concern. In addition to increasing the immediate risk of gestational complications, there is accumulating evidence that maternal obesity also has long-term consequences for the offspring. The concept of developmental programming describes the process in which an environmental stimulus, including altered nutrition, during critical periods of development can program alterations in organogenesis, tissue development, and metabolism, predisposing offspring to obesity and metabolic and cardiovascular disorders in later life. Although the mechanisms underpinning programming of metabolic disorders remain poorly defined, it has become increasingly clear that low-grade inflammation is associated with obesity and its comorbidities. This review will discuss maternal metainflammation as a mediator of programming in insulin sensitive tissues in offspring. Use of nutritional anti-inflammatories in pregnancy including omega 3 fatty acids, resveratrol, curcumin, and taurine may provide beneficial intervention strategies to ameliorate maternal obesity-induced programming.

PubMed Disclaimer

Similar articles

Cited by

References

    1. Heslehurst N, Ells LJ, Simpson H, Batterham A, Wilkinson J, Summerbell CD. Trends in maternal obesity incidence rates, demographic predictors, and health inequalities in 36,821 women over a 15-year period. BJOG. 2007;114(2):187–194. - PubMed
    1. Heslehurst N, Sattar N, Rajasingam D, Wilkinson J, Summerbell CD, Rankin J. Existing maternal obesity guidelines may increase inequalities between ethnic groups: a national epidemiological study of 502,474 births in England. BMC Pregnancy & Childbirth. 2012;12(1, article 156) - PMC - PubMed
    1. Flegal KM, Carroll MD, Ogden CL, Curtin LR. Prevalence and trends in obesity among US adults, 1999–2008. Journal of the American Medical Association. 2010;303(3):235–241. - PubMed
    1. Catalano PM, Ehrenberg HM. The short- and long-term implications of maternal obesity on the mother and her offspring. BJOG. 2006;113(10):1126–1133. - PubMed
    1. Alfaradhi MZ, Ozanne SE. Developmental programming in response to maternal overnutrition. Frontiers in Genetics. 2011;2, article 27 - PMC - PubMed

Publication types

MeSH terms

Substances

LinkOut - more resources