Triglyceride is strongly associated with nonalcoholic fatty liver disease among markers of hyperlipidemia and diabetes - PubMed (original) (raw)

Triglyceride is strongly associated with nonalcoholic fatty liver disease among markers of hyperlipidemia and diabetes

Minoru Tomizawa et al. Biomed Rep. 2014 Sep.

Abstract

The aim of the present study was to reveal the metabolic disorders most commonly associated with nonalcoholic fatty liver disease (NAFLD). Triglyceride (TG), high-density lipoprotein cholesterol (HDL), low-density lipoprotein cholesterol (LDL), blood glucose (BG) and hemoglobin A1c (HbA1c) were analyzed. NAFLD was diagnosed using abdominal ultrasound (US), and TG, HDL, LDL, BG and HbA1c were immediately collected on the same day and subjected to multivariate regression analysis. Stepwise analysis was performed to select the variables that were closely associated with NAFLD. The patients who were positive for the hepatitis B antigen and hepatitis C antibody were excluded from the study. Additionally, the patients who were prescribed prednisolone or methotrexate were excluded from the study as these agents may cause NAFLD or liver toxicity. The study included 168 and 125 patients with and without NAFLD, respectively. TG, BG and HbA1c were strongly correlated with NAFLD. Among these parameters, TG was the strongest predictor of NAFLD (χ2=9.89, P=0.0017). TG was the parameter that was most strongly associated with NAFLD. In conclusion, elevated TG was a marker of NAFLD.

Keywords: blood glucose; hemoglobin A1c; multivariate regression analysis; receiver operating characteristics.

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Figures

Figure 1

Figure 1

Receiver operator characteristic (ROC) for the prediction of nonalcoholic fatty liver with the logistic model. The ROC curve was illustrated to evaluate the usefulness of the logistic model to predict nonalcoholic fatty liver disease. Solid straight line, a line with a slope of 45° to calculate the threshold value by the software (JMP 10.0.2); broken line, reference.

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