Association between habitual physical activity and brown adipose tissue activity in individuals undergoing PET-CT scan - PubMed (original) (raw)

doi: 10.1111/cen.12620. Epub 2014 Oct 27.

Affiliations

• PMID: 25262810
• DOI: 10.1111/cen.12620

Association between habitual physical activity and brown adipose tissue activity in individuals undergoing PET-CT scan

Petros C Dinas et al. Clin Endocrinol (Oxf). 2015 Jan.

Abstract

Objective: Augmented brown adipose tissue (BAT) mass and activity lead to higher basic metabolic rate which is beneficial against obesity. Our aim was to investigate whether habitual (i.e. usual weekly participation) physical activity is linked with BAT activity and mass in humans, in a group of patients undergoing (18) F-fluorodeoxyglucose positron emission tomography/computed tomography (PET/CT) scanning.

Design: Cross-sectional study.

Patients: Forty patients with cancer [26 male; 14 female; age 52·7 ± 17·5; body mass index (BMI) 26·4 ± 4·5].

Measurements: Patients completed the 'usual week' form of the International Physical Activity Questionnaire and underwent assessment of BAT activity/mass via (18) F-fluorodeoxyglucose PET/CT.

Results: We detected a significant association between habitual physical activity (METs-minute/week) and BAT activity [normalized by body weight (BW) (τ = 0·28, P = 0·02), body surface area (BSA) (τ = 0·29, P = 0·02) and lean body mass (LBM) (τ = 0·38, P = 0·002)]. We also found a significant negative relationship between BMI and BAT activity [normalized by BW (τ = -0·30, P = 0·006), BSA (τ = -0·31, P = 0·004) and LBM (τ = -0·45, P = 0·001)] as well as a significant negative relationship between age and BAT activity [normalized by LBM (τ = -0·28, P = 0·01)]. The results also indicate significant differences between low/moderate/high levels of habitual physical activity and BAT activity (P < 0·05). Moreover, BAT activity was different across the BMI categories (normal/overweight/obese) in both sexes (P < 0·05). Finally, BAT activity was greater in women than in men (P < 0·05).

Conclusions: Increased participation in habitual physical activity is associated with higher BAT activity. Moreover, individuals with normal BMI demonstrate higher BAT activity compared to overweight and obese individuals. Finally, age is inversely linked with BAT activity, while women demonstrate higher BAT activity than men.

© 2014 John Wiley & Sons Ltd.

PubMed Disclaimer

Comment in

• RE: Association between habitual physical activity and brown adipose tissue activity in individuals undergoing PET-CT scan.
  Ruiz JR, Sánchez-Delgado G, Martínez-Téllez B, Aguilera CM, Gil A. Ruiz JR, et al. Clin Endocrinol (Oxf). 2015 Oct;83(4):590-1. doi: 10.1111/cen.12703. Epub 2015 Jan 15. Clin Endocrinol (Oxf). 2015. PMID: 25521222 No abstract available.
• Impact of regular exercise on classical brown adipose tissue.
  Flouris AD, Dinas PC. Flouris AD, et al. Clin Endocrinol (Oxf). 2015 Oct;83(4):591-3. doi: 10.1111/cen.12716. Epub 2015 Feb 14. Clin Endocrinol (Oxf). 2015. PMID: 25580858 No abstract available.

Similar articles

• Age-related decrease in cold-activated brown adipose tissue and accumulation of body fat in healthy humans.
  Yoneshiro T, Aita S, Matsushita M, Okamatsu-Ogura Y, Kameya T, Kawai Y, Miyagawa M, Tsujisaki M, Saito M. Yoneshiro T, et al. Obesity (Silver Spring). 2011 Sep;19(9):1755-60. doi: 10.1038/oby.2011.125. Epub 2011 May 12. Obesity (Silver Spring). 2011. PMID: 21566561
• The effects of thyroid hormones on brown adipose tissue in humans: a PET-CT study.
  Zhang Q, Miao Q, Ye H, Zhang Z, Zuo C, Hua F, Guan Y, Li Y. Zhang Q, et al. Diabetes Metab Res Rev. 2014 Sep;30(6):513-20. doi: 10.1002/dmrr.2556. Diabetes Metab Res Rev. 2014. PMID: 24823620
• Correlation of Brown Adipose Tissue with Other Body Fat Compartments and Patient Characteristics: A Retrospective Analysis in a Large Patient Cohort Using PET/CT.
  Brendle C, Werner MK, Schmadl M, la Fougère C, Nikolaou K, Stefan N, Pfannenberg C. Brendle C, et al. Acad Radiol. 2018 Jan;25(1):102-110. doi: 10.1016/j.acra.2017.09.007. Epub 2017 Nov 3. Acad Radiol. 2018. PMID: 29108812
• Brown adipose tissue and the regulation of nonshivering thermogenesis.
  van Marken Lichtenbelt W. van Marken Lichtenbelt W. Curr Opin Clin Nutr Metab Care. 2012 Nov;15(6):547-52. doi: 10.1097/MCO.0b013e3283599184. Curr Opin Clin Nutr Metab Care. 2012. PMID: 23037904 Review.
• Relevance of brown adipose tissue in infancy and adolescence.
  Gilsanz V, Hu HH, Kajimura S. Gilsanz V, et al. Pediatr Res. 2013 Jan;73(1):3-9. doi: 10.1038/pr.2012.141. Epub 2012 Oct 22. Pediatr Res. 2013. PMID: 23090604 Free PMC article. Review.

Cited by

• Effect of Chronic Athletic Activity on Brown Fat in Young Women.
  Singhal V, Maffazioli GD, Ackerman KE, Lee H, Elia EF, Woolley R, Kolodny G, Cypess AM, Misra M. Singhal V, et al. PLoS One. 2016 May 31;11(5):e0156353. doi: 10.1371/journal.pone.0156353. eCollection 2016. PLoS One. 2016. PMID: 27243823 Free PMC article.
• Dietary Intake Is Similar Among Adult Men with Different Levels of Cold-Induced Brown Adipose Tissue Activation.
  Carrillo AE, Dinas PC, Krase A, Nintou E, Georgakopoulos A, Metaxas M, Ryan EJ, Vliora M, Georgoulias P, Chatziioannou S, Flouris AD. Carrillo AE, et al. Nutrients. 2024 Oct 30;16(21):3697. doi: 10.3390/nu16213697. Nutrients. 2024. PMID: 39519530 Free PMC article.
• Prior exercise training blunts short-term high-fat diet-induced weight gain.
  Snook LA, MacPherson RE, Monaco CM, Frendo-Cumbo S, Castellani L, Peppler WT, Anderson ZG, Buzelle SL, LeBlanc PJ, Holloway GP, Wright DC. Snook LA, et al. Am J Physiol Regul Integr Comp Physiol. 2016 Aug 1;311(2):R315-24. doi: 10.1152/ajpregu.00072.2016. Epub 2016 Apr 13. Am J Physiol Regul Integr Comp Physiol. 2016. PMID: 27101294 Free PMC article.
• Effects of Nutrition/Diet on Brown Adipose Tissue in Humans: A Systematic Review and Meta-Analysis.
  Heenan KA, Carrillo AE, Fulton JL, Ryan EJ, Edsall JR, Rigopoulos D, Markofski MM, Flouris AD, Dinas PC. Heenan KA, et al. Nutrients. 2020 Sep 10;12(9):2752. doi: 10.3390/nu12092752. Nutrients. 2020. PMID: 32927664 Free PMC article.
• Incidental finding of low brown adipose tissue activity in endurance-trained individuals: Methodological considerations for positron emission tomography.
  Trexler ET, McCallister D, Smith-Ryan AE, Branca RT. Trexler ET, et al. J Nat Sci. 2017 Mar;3(3):e335. J Nat Sci. 2017. PMID: 28580427 Free PMC article.

Publication types

MeSH terms

LinkOut - more resources

• Full Text Sources

  • Wiley

• Other Literature Sources

  • The Lens - Patent Citations Database
  • scite Smart Citations