T-cell tolerance by clonal anergy in transgenic mice with nonlymphoid expression of MHC class II I-E - PubMed (original) (raw)
. 1989 Nov 30;342(6249):564-6.
doi: 10.1038/342564a0.
Affiliations
- PMID: 2531293
- DOI: 10.1038/342564a0
T-cell tolerance by clonal anergy in transgenic mice with nonlymphoid expression of MHC class II I-E
L C Burkly et al. Nature. 1989.
Abstract
T-cell reactivity to the class II major histocompatibility complex I-E antigen is associated with T-cell antigen receptors containing the V beta gene segments V beta 17a and V beta 5. Mice expressing I-E with the normal tissue distribution (on B cells, macrophages, dendritic cells and thymic epithelium) induce tolerance to self I-E by clonal deletion in the thymus. By contrast, we find that transgenic INS-I-E mice that express I-E on pancreatic beta-cells, but not in the thymus or peripheral lymphoid organs, are tolerant to I-E but have not deleted V beta 5- and V beta 17a-bearing T cells. Moreover, whereas T-cell populations from nontransgenic mice proliferate in response to receptor crosslinking with V beta 5- and V beta 17a-specific antibodies, T cells from INS-I-E mice do not. Thus, our experiments provide direct evidence that T-cell tolerance by clonal paralysis does occur during normal T-cell development in vivo.
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